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Genetic variants in Alzheimer's disease

Author: Kevin Morgan; Minerva M Carrasquillo
Publisher: New York, NY : Springer, ©2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Since 2009, a revolution has been witnessed in Alzheimer's Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer's disease (LOAD) based on evidence of genetic  Read more...
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Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Kevin Morgan; Minerva M Carrasquillo
ISBN: 9781461473091 1461473098 9781461473084 146147308X
OCLC Number: 851375470
Notes: Includes index.
Description: 1 online resource.
Contents: The Genetics of Alzheimer's Disease: Introduction and Perspective for the Future / Kevin Morgan, Minerva M. Carrasquillo --
Apolipoprotein E / Minerva M. Carrasquillo, Guojun Bu --
Clusterin / Jenny Lord, Kevin Morgan --
PICALM / Jenny Lord, Kevin Morgan --
Complement Component (3b/4b) Receptor 1 (CR1) / Jenny Lord, Kevin Morgan --
Bridging Integrator 1 (BIN1) / James Turton, Kevin Morgan --
ATP-Binding Cassette, Subfamily A (ABC1), Member 7 (ABCA7) / James Turton, Kevin Morgan --
Membrane-Spanning 4-Domains Subfamily A, MS4A Cluster / Kristelle Brown, James Turton, Kevin Morgan --
Sialic Acid Binding Immunoglobulin-Like Lectin-3 (CD33) / Christopher Medway, Kevin Morgan --
Erythropoietin-Producing Human Hepatocellular Carcinoma (EphA1) / Christopher Medway, Anne Braae, Kevin Morgan --
CD2-Associated Protein (CD2AP) / Christopher Medway, Kevin Morgan --
Other Genes Implicated in Alzheimer's Disease / Minerva M. Carrasquillo Ph.D. --
The Future Role of Biomarkers in Alzheimer's Disease Diagnostics / Joanna L. Richens, Bharak Vafadar-Isfahani.
Responsibility: Kevin Morgan, Minerva M. Carrasquillo, editors.

Abstract:

Since 2009, a revolution has been witnessed in Alzheimer's Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer's disease (LOAD) based on evidence of genetic association. These "AD susceptibility genes" are described both in their genomic and cellular context, as well as with respect to their known or suspected molecular functions. Although these genes are not sufficient to explain all of the genetic contributions to LOAD, they represent the best replicated set of genes to date. Undoubtedly the list will grow as more advanced genomic approaches towards the identification of novel LOAD genes progresses.

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