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Genetically engineered mice for cancer research : design, analysis, pathways, validation and pre-clinical testing

Author: Jeff Green; Thomas Ried
Publisher: New York : Springer Science+Business Media, LLC, ©2012.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

This book reviews state-of-the-art methods for generating, analyzing and validating genetically-engineered mouse models for studying human cancer biology. Coverage includes the use of mouse models in  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Genetically Engineered Mice for Cancer Research.
Springer Verlag 2011
(OCoLC)758395325
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jeff Green; Thomas Ried
ISBN: 9780387698052 0387698051
OCLC Number: 769755409
Description: 1 online resource (xx, 632 pages) : illustrations (some color)
Contents: Overview of designing genetically engineered mouse (GEM) models --
Use of Cre-loxP technology and inducible systems to generate mouse models of cancer --
Using recombineering technology to create genetically engineered mouse models --
Insertional mutagenesis for generating mouse models of cancer --
RCAS/TVA somatic gene transfer method in modeling human cancer --
Target-selected ENU mutagenesis to develop cancer models in the rat --
Tumor pathology of genetically engineered mice: genomic pathology --
Genomic DNA copy number alterations in mouse cancer models and human cancer --
Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry --
Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing --
Imaging mouse models of human cancer --
Identifying mammary epithelial stem and progenitor cells --
Differentiation programs in development and cancer --
Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse --
Mouse models for colorectal cancer --
Src family tyrosine kinases: implications for mammary tumor progression --
Maspin and suppresion of tumor metastasis --
Epigenetic mouse models --
Modeling transforming growth factor-ß signalling in cancer --
Modeling stromal-epithelial interactions --
Utilizing mouse models of human cancer for assessing immune modulation of cancer development --
Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models --
Development and use of genetically tractable preclinical mouse models --
Animal models for breast cancer prevention research --
Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies --
Mouse models in preclinical drug development: applications to CNS models --
Mouse models of human cancer: role in preclinical testing and personalized medicine --
Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
Responsibility: Jeffrey E. Green, Thomas Ried, editors.

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