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Genetics of bipolar disorder

Author: Susanne Bengesser; Eva Reininghaus
Publisher: Frankfurt am Main ; New York : PL Academic Research/Peter Lang, [2013] ©2013
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The high hereditary factor of Bipolar Disorder has been proven by many twin-, adoption- and family-studies already decades ago. Concordance rates between monozygotic twins are even as high as 40-70%. Children of two affected parents have a lifetime-risk of 50-65% to fall ill with Bipolar Disorder, while children with one affected parent show a risk of 25% to get Bipolar Disorder. Therefore psychiatric genetics is  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Bengesser, Susanne, 1983-
Genetics of bipolar disorder
(DLC) 2013011915
(OCoLC)833147441
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Susanne Bengesser; Eva Reininghaus
ISBN: 9783653030365 3653030366
OCLC Number: 858861841
Description: 1 online resource (226 pages)
Contents: Cover; Preface; Abstract; Acknowledgements; Table of Contents; 1. Introduction; 1.1 Bipolar Affective Disorder; 1.1.1 History and Symptomatology of Bipolar Disorder; 1.1.2 Pharmacotherapy; Mood Stabilization; Lithium; Antiepileptics; Atypical Antipsychotics; Antidepressant Therapy; Selective Serotonin Reuptake Inhibitors (SSRI); NASSA (Noradrenaline and Serotonin Specific Antidepressant); SNRI (Serotonin and Noradrenaline Reuptake Inhibitor); NARI (Noradrenaline Reuptake Inhibitor); SRE (Serotonin Reuptake Enhancer); NDRI (Noradrenaline and Dopamine Reuptake Inhibitor). Tricyclic AntidepressantsTetracyclic Antidepressants; MAO Inhibitors; DSA (Dual Serotonergic Antidepressant); Bright Light Therapy; 1.1.3 Epidemiology of Bipolar Disorder; 1.2 Basic Principles of Genetics; 1.2.1 Structure of DNA; 1.2.2 Gene Expression- from DNA to Proteins; Transcription; Initiation of Transcription; Elongation of Transcription; Termination of Transcription; Proteinbiosynthesis (Translation):; Initiation of Protein Biosynthesis in Eukaryotes; Elongation; Termination; 1.2.3 Replication; Initiation of Replication; 1.2.4 Epigenetics; 1.2.5 Mutations; Gene mutations. Point mutationsInsertions, Deletions, Duplications and Repeat Polymorphisms; Chromosomal mutations; Structural Chromosomal Mutations; Chromosome Number Aberrations; 1.2.6 Methods of Molecular Bipolar Disorder Research; Association Studies; Genome Wide Association Studies (GWAS); Linkage studies; 2. Methods; 3. Genetics of Bipolar Disorder; 3.1 Heritability of Bipolar Disorder; 3.2 Candidate Genes at One View; 3.3 Genes of the Serotonergic System; 3.3.1 Serotonin Receptor Genes; 5-HT1 Receptor Genes; HTR1A; Promoter Polymorphism -1019C/G (rs6295); G659T Polymorphism. Dinucleotide Polymorphism (CAn/GTn repeats)Relevance for Therapy; HTR1B and HTR1D; 5-HT2 Receptor Genes; HTR2A; T102C; Msp1; 516-C/T; 1354C/T; His452Tyr; Thr25Asn; -A1438G Genetic Polymorphism; Linkage studies; HTR2C Gene; 5-HT3 Receptor Genes; 5-HT4 Receptor Genes; 5-HT5 Receptor Genes; 5-HT6 Receptor Genes; 5-HT7 Receptor Genes; 3.3.2 Serotonin Transporter Gene (= SLC6A4, SERT, 5HTT); Polymorphism of the 5-HTTLPR and the Untranslated Region; The Variable-Number-Tandem-Repeat (VNTR) within Intron 2; Insertion/deletion in the Promoter Region of the Serotonin Transporter. 3.4 Genes Involved in Biogenic Amine Modulation3.4.1 MAOA; Animal Studies; Antidepressants; Association Studies; CA-Repeat Microsatellite in Intron 2; Fnu4H1 RFLP (Fnu4H1 Restriction Fragment Length Polymorphism); Fnu4H1; Fnu4H1; EcoRV Polymorphism (T-to-C Substitution at Position-1460); EcoRV; EcoRV; T-to-A Substitution at Position 1077 (Promoter VNTR); Variable Number of Tandem Repeats (VNTR) Polymorphism in Intron 1; Linkage studies; 3.4.2 MAOB; 3.4.3 COMT; 3.4.4 TPH; 3.4.5 TH; 3.5 Clock Genes; 3.5.1 The Circadian Oscillator in the Suprachiasmatic Nucleus.
Responsibility: Susanne Bengesser, Eva Reininghaus.

Abstract:

The high hereditary factor of Bipolar Disorder has been proven by many twin-, adoption- and family-studies already decades ago. A detailed and exciting description is given within this book.  Read more...

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