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Genetics of complex human diseases : a laboratory manual

Author: Ammar Al-Chalabi; Laura Almasy
Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, ©2009.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:
Many human diseases including Alzheimer's disease, schizophrenia, cancer, and cardiovascular disease have complex genetics that require sophisticated analysis. Tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage  Read more...
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Document Type: Book
All Authors / Contributors: Ammar Al-Chalabi; Laura Almasy
ISBN: 9780879698829 0879698829 9780879698836 0879698837
OCLC Number: 402542181
Description: ix, 220 p. : ill. (some col.) ; 29 cm.
Responsibility: edited by Ammar Al-Chalabi, Laura Almasy.

Abstract:

Many human diseases including Alzheimer's disease, schizophrenia, cancer, and cardiovascular disease have complex genetics that require sophisticated analysis. Tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book's chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis.

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