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Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.
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Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.

Author: L Vítek Affiliation: 4th Department of Internal Medicine, 1st Medical Faculty, Charles University Prague, U Nemocnice 2, 128 08 Prague, Czech Republic. vitek@cesnet.czM JirsaM BrodanováM KalabZ MarecekAll authors
Edition/Format: Article Article : English
Publication:Atherosclerosis, 2002 Feb; 160(2): 449-56
Other Databases: WorldCatWorldCat
Summary:
BACKGROUND: Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS: The occurrence of IHD was determined in Gilbert syndrome (GS) patients above 40 years (n=50). The diagnosis was based on past medical history and ECG  Read more...
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Document Type: Article
All Authors / Contributors: L Vítek Affiliation: 4th Department of Internal Medicine, 1st Medical Faculty, Charles University Prague, U Nemocnice 2, 128 08 Prague, Czech Republic. vitek@cesnet.cz; M Jirsa; M Brodanová; M Kalab; Z Marecek; V Danzig; L Novotný; P Kotal
ISSN:0021-9150
Language Note: English
Unique Identifier: 121255719
Awards:

Abstract:

BACKGROUND: Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS: The occurrence of IHD was determined in Gilbert syndrome (GS) patients above 40 years (n=50). The diagnosis was based on past medical history and ECG criteria. The occurrence was related to that of the comparable general population (n=2296). Serum biochemistry, including the total antioxidant status was evaluated in the GS subjects, IHD patients (n=38) and control subjects (n=38). RESULTS: The prevalence of IHD in GS subjects (aged 49.7+/-9.0 years) was 2% (0.05-10.7%, 95% confidence interval), compared to 12.1% in a general population (P<0.05). Bilirubin, total antioxidant capacity and high density lipoprotein (HDL) cholesterol were found to be significantly higher in GS subjects compared to control groups (P<0.05). According to linear discriminant analysis, hyperbilirubinemia rather than elevation of HDL cholesterol levels seemed to be more important in protection from IHD. CONCLUSIONS: In the present study, low prevalence of IHD in GS subjects was detected. It may be presumed that chronic hyperbilirubinemia prevent the development of IHD by increasing the serum antioxidant capacity.

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    schema:contributor <http://experiment.worldcat.org/entity/work/data/77645127#Person/kalab_m> ; # Kalab M
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    schema:description "CONCLUSIONS: In the present study, low prevalence of IHD in GS subjects was detected. It may be presumed that chronic hyperbilirubinemia prevent the development of IHD by increasing the serum antioxidant capacity." ;
    schema:description "METHODS: The occurrence of IHD was determined in Gilbert syndrome (GS) patients above 40 years (n=50). The diagnosis was based on past medical history and ECG criteria. The occurrence was related to that of the comparable general population (n=2296). Serum biochemistry, including the total antioxidant status was evaluated in the GS subjects, IHD patients (n=38) and control subjects (n=38)." ;
    schema:description "RESULTS: The prevalence of IHD in GS subjects (aged 49.7+/-9.0 years) was 2% (0.05-10.7%, 95% confidence interval), compared to 12.1% in a general population (P<0.05). Bilirubin, total antioxidant capacity and high density lipoprotein (HDL) cholesterol were found to be significantly higher in GS subjects compared to control groups (P<0.05). According to linear discriminant analysis, hyperbilirubinemia rather than elevation of HDL cholesterol levels seemed to be more important in protection from IHD." ;
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