skip to content
Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease Preview this item
ClosePreview this item
Checking...

Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease

Author: Michael A Sirover
Publisher: London : Academic Press, an imprint of Elsevier, 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Michael A Sirover
ISBN: 9781351935623 1351935623 9780128098981 0128098988
OCLC Number: 988291290
Description: 1 online resource
Contents: Section I. The Role of Moonlighting GAPDH in Normal Cell Function. The role of moonlighting GAPDH in cell proliferation : the dynamic nature of GAPDH expression and subcellular localization --
Moonlighting GAPDH and the transcriptional regulation of gene expression : multiprotein complex formation and mechanisms of nuclear translocation --
The diversity of moonlighting GAPDH function in posttranscriptional RNA regulation : mRNA stability, tRNA processing, and viral pathogenesis --
The role of moonlighting GAPDH in membrane structure and function : membrane fusion and iron metabolism --
The role of moonlighting GAPDH in intracellular membrane trafficking : tubulin regulation and modulation of cytoskeletal structure --
Moonlighting GAPDH and the maintenance of DNA integrity : preservation of genetic information and cancer facilitation --
Moonlighting GAPDH in neuronal structure and function : regulation of ion channels and signal transduction --
Section II. Physiological Stress and GAPDH Functional Diversity. The significance of nitric oxide-modified GAPDH : regulation of apoptosis, cell signaling, and heme metabolism --
GAPDH and hypoxia : mechanisms of cell survival during oxygen deprivation --
Moonlighting GAPDH and ischemia : cellular and molecular effects of oxygen deprivation and reperfusion --
Section II. The Pathology of GAPDH Functional Diversity. GAPDH and tumorigenesis : molecular mechanisms of cancer development and survival --
Moonlighting GAPDH and age-related neurodegenerative disease : diversity of protein interactions and complexity of function --
Functional diversity of GAPDH in infection and immunity : the complexity of "simple" organisms --
Moonlighting GAPDH and diabetes : pleiotropic effects of perturbations in GAPDH structure and function --
Section IV. The Pharmacology of Moonlighting GAPDH --
Section V. The Unique Role of Sperm-Specific GAPDH --
Section VI. Discussion.
Responsibility: Michael A. Sirover.

Abstract:

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/988291290> # Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease
    a schema:Book, schema:CreativeWork, schema:MediaObject ;
    library:oclcnum "988291290" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/enk> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4092746763#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/4092746763#Topic/glycolysis> ; # Glycolysis
    schema:about <http://dewey.info/class/572.791/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4092746763#Topic/aldehyde_dehydrogenase> ; # Aldehyde Dehydrogenase
    schema:author <http://experiment.worldcat.org/entity/work/data/4092746763#Person/sirover_michael_a> ; # Michael A. Sirover
    schema:bookFormat schema:EBook ;
    schema:datePublished "2017" ;
    schema:description "Section I. The Role of Moonlighting GAPDH in Normal Cell Function. The role of moonlighting GAPDH in cell proliferation : the dynamic nature of GAPDH expression and subcellular localization -- Moonlighting GAPDH and the transcriptional regulation of gene expression : multiprotein complex formation and mechanisms of nuclear translocation -- The diversity of moonlighting GAPDH function in posttranscriptional RNA regulation : mRNA stability, tRNA processing, and viral pathogenesis -- The role of moonlighting GAPDH in membrane structure and function : membrane fusion and iron metabolism -- The role of moonlighting GAPDH in intracellular membrane trafficking : tubulin regulation and modulation of cytoskeletal structure -- Moonlighting GAPDH and the maintenance of DNA integrity : preservation of genetic information and cancer facilitation -- Moonlighting GAPDH in neuronal structure and function : regulation of ion channels and signal transduction -- Section II. Physiological Stress and GAPDH Functional Diversity. The significance of nitric oxide-modified GAPDH : regulation of apoptosis, cell signaling, and heme metabolism -- GAPDH and hypoxia : mechanisms of cell survival during oxygen deprivation -- Moonlighting GAPDH and ischemia : cellular and molecular effects of oxygen deprivation and reperfusion -- Section II. The Pathology of GAPDH Functional Diversity. GAPDH and tumorigenesis : molecular mechanisms of cancer development and survival -- Moonlighting GAPDH and age-related neurodegenerative disease : diversity of protein interactions and complexity of function -- Functional diversity of GAPDH in infection and immunity : the complexity of "simple" organisms -- Moonlighting GAPDH and diabetes : pleiotropic effects of perturbations in GAPDH structure and function -- Section IV. The Pharmacology of Moonlighting GAPDH -- Section V. The Unique Role of Sperm-Specific GAPDH -- Section VI. Discussion."@en ;
    schema:description "Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4092746763> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:name "Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease"@en ;
    schema:productID "988291290" ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=4865053> ;
    schema:url <https://nls.ldls.org.uk/welcome.html?ark:/81055/vdc_100044611412.0x000001> ;
    schema:url <http://www.myilibrary.com?id=1010517> ;
    schema:url <http://www.sciencedirect.com/science/book/9780128098523> ;
    schema:url <https://www.sciencedirect.com/science/book/9780128098523> ;
    schema:url <http://www.myilibrary.com?id=1012373> ;
    schema:url <http://0-www.sciencedirect.com.pugwash.lib.warwick.ac.uk/science/book/9780128098523> ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1188523> ;
    schema:url <http://dproxy.library.dc-uoit.ca/login?url=https://www.sciencedirect.com/science/book/9780128098523> ;
    schema:workExample <http://worldcat.org/isbn/9780128098981> ;
    schema:workExample <http://worldcat.org/isbn/9781351935623> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/988291290> ;
    .


Related Entities

<http://dproxy.library.dc-uoit.ca/login?url=https://www.sciencedirect.com/science/book/9780128098523>
    rdfs:comment "eBook available for Durham College via Elsevier. Click link to access" ;
    .

<http://experiment.worldcat.org/entity/work/data/4092746763#Person/sirover_michael_a> # Michael A. Sirover
    a schema:Person ;
    schema:familyName "Sirover" ;
    schema:givenName "Michael A." ;
    schema:name "Michael A. Sirover" ;
    .

<http://experiment.worldcat.org/entity/work/data/4092746763#Topic/aldehyde_dehydrogenase> # Aldehyde Dehydrogenase
    a schema:Intangible ;
    schema:name "Aldehyde Dehydrogenase"@en ;
    schema:name "Aldehyde dehydrogenase"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4092746763#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://worldcat.org/isbn/9780128098981>
    a schema:ProductModel ;
    schema:isbn "0128098988" ;
    schema:isbn "9780128098981" ;
    .

<http://worldcat.org/isbn/9781351935623>
    a schema:ProductModel ;
    schema:isbn "1351935623" ;
    schema:isbn "9781351935623" ;
    .

<http://www.worldcat.org/title/-/oclc/988291290>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/988291290> ; # Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease
    schema:dateModified "2018-09-13" ;
    void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.