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Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease

Author: Michael A Sirover
Publisher: London : Academic Press, an imprint of Elsevier, 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Michael A Sirover
ISBN: 9781351935623 1351935623 9780128098981 0128098988
OCLC Number: 988291290
Description: 1 online resource
Contents: Section I. Moonlighting GAPDH in Normal Cell Function 1. Transcriptional Expression 2. Post-translational mRNA Regulation 3. Iron Metabolism 4. Membrane Trafficking 5. Maintenance of DNA Integrity 6. GAPDH and Neural Transmission 7. GAPDH and Cell Proliferation Section II. Physiological Stress and GAPDH Functional Diversity 1. GAPDH and Oxidative Stress: Nitric Oxide, apoptosis and heme metabolism 2. GAPDH and Hypoxia 3. GAPDH and Ischemia. Ischemia may be defined as a restriction in blood supply to tissues resulting in oxygen deprivation. Recent studies indicate that moonlighting GAPDH may be specifically regulated as a function of ischemic stress. This includes its role in receptor mediated glutamate exocytosis and its intracellular interaction with the p53 protein. The former regulates AMPAR action while the latter involves the formation of a GAPDH:p53 protein-protein complex as well as post-translational modification of the p53 protein. Section III. The Pathology of GAPDH Functional Diversity 1. GAPDH and Age-Related Neurodegenerative Disease 2. Moonlighting GAPDH and Cancer Development 3. Functional Diversity of GAPDH in Infection and Immunity Section IV. The Pharmacology of Moonlighting GAPDH Section V. Discussion
Responsibility: Michael A. Sirover.

Abstract:

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease.

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