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|All Authors / Contributors:||
|Description:||xxi, 520 p.,  p. of plates : ill. (some col.) ; 25 cm.|
|Contents:||The evolution of receptors : from on-off switches to microprocessors / Terry Kenakin --
The evolving pharmacology of GPCRs / Lauren T. May, Nicholas D. Holliday, and Stephen J. Hill --
The emergence of allosteric modulators for G protein-coupled receptors / Karen J. Gregory ... et al. --
Receptor-mediated G protein activation : How, how many, and where? / Ingrid Gsandtner, Christian W. Gruber, and Michael Freissmuth --
Molecular pharmacology of frizzleds --
with implications for possible therapy / Gunnar Schulte --
Secretin recpetor dimerization : a possible functionally important paradigm for family B G protein-coupled receptors / Kaleeckal G. Harikumar, Maoqing Dong, and Laurence J. Miller --
Past and future strategies for GPCR deorphanization / Angelique Levoye ... [et al.] --
High-throughput GPCR screening technologies and the emerging importance of the cell phenotype / Terry Reisine and Richard M. Eglen --
Are "traditional" biochemical techniques out of fashion in the new era of GPCR pharmacology? / Maria Teresa Dell'anno and Maria Rosa Mazzoni --
Fluorescence and resonance energy transfer shine new light on GPCR function / Carsten Hoffmann and Moritz Bünemann --
Integration of lable-free detection methods in GPCR drug discovery / Oliver Nayler, Magdalena Birker-Robaczewska, and John Gatfield --
Screening for allosteric modulators of G protein-coupled receptors / Christopher Langmead --
Ultra-high throughput screening assays for GPCRs / Priya Kunapuli --
New techniques to express and crystallize G protein-coupled receptors / James C. Errey and Fiona H. Marshall --
Structure and modeling of GPCRs : implications for drug discovery / Kimberly A. Reynolds, Vsevolod Katritch and Ruben Abagyan --
X-ray structure developments for GPCR drug targets / Michael Sabio and Sidney W. Topiol --
Pharmacological chaperones : potential for the treatment of hereditary diseases caused by mutations in G protein-coupled receptors / Kenneth J. Valenzano ... et al.
|Responsibility:||edited by Annette Gilchrist.|
"Additionally, the presentation of the fundamental concepts of GPCR biology by the authors, who are recognized experts in the GPCR field, is likely to be appreciated by students of pharmacology...