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GPCR molecular pharmacology and drug targeting : shifting paradigms and new directions

Author: Annette Gilchrist
Publisher: Hoboken, N.J. : Wiley, ©2010.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

* G protein-coupled receptors (GPCRs), are a large protein familyof transmembrane receptors that sense molecules outside the celland activate inside signal transduction pathways and,  Read more...

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Document Type: Book
All Authors / Contributors: Annette Gilchrist
ISBN: 9780470307786 0470307781
OCLC Number: 489623096
Description: xxi, 520 pages, [16] pages of plates : illustrations (some color) ; 25 cm
Contents: The evolution of receptors : from on-off switches to microprocessors / Terry Kenakin --
The evolving pharmacology of GPCRs / Lauren T. May, Nicholas D. Holliday, and Stephen J. Hill --
The emergence of allosteric modulators for G protein-coupled receptors / Karen J. Gregory ... et al. --
Receptor-mediated G protein activation : How, how many, and where? / Ingrid Gsandtner, Christian W. Gruber, and Michael Freissmuth --
Molecular pharmacology of frizzleds --
with implications for possible therapy / Gunnar Schulte --
Secretin recpetor dimerization : a possible functionally important paradigm for family B G protein-coupled receptors / Kaleeckal G. Harikumar, Maoqing Dong, and Laurence J. Miller --
Past and future strategies for GPCR deorphanization / Angelique Levoye [and others] --
High-throughput GPCR screening technologies and the emerging importance of the cell phenotype / Terry Reisine and Richard M. Eglen --
Are "traditional" biochemical techniques out of fashion in the new era of GPCR pharmacology? / Maria Teresa Dell'anno and Maria Rosa Mazzoni --
Fluorescence and resonance energy transfer shine new light on GPCR function / Carsten Hoffmann and Moritz Bünemann --
Integration of lable-free detection methods in GPCR drug discovery / Oliver Nayler, Magdalena Birker-Robaczewska, and John Gatfield --
Screening for allosteric modulators of G protein-coupled receptors / Christopher Langmead --
Ultra-high throughput screening assays for GPCRs / Priya Kunapuli --
New techniques to express and crystallize G protein-coupled receptors / James C. Errey and Fiona H. Marshall --
Structure and modeling of GPCRs : implications for drug discovery / Kimberly A. Reynolds, Vsevolod Katritch and Ruben Abagyan --
X-ray structure developments for GPCR drug targets / Michael Sabio and Sidney W. Topiol --
Pharmacological chaperones : potential for the treatment of hereditary diseases caused by mutations in G protein-coupled receptors / Kenneth J. Valenzano ... et al.
Responsibility: edited by Annette Gilchrist.

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"Additionally, the presentation of the fundamental concepts of GPCR biology by the authors, who are recognized experts in the GPCR field, is likely to be appreciated by students of pharmacology... Read more...

 
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