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GPCRs : from deorphanization to lead structure identification

Author: Henry R Bourne
Publisher: Berlin ; New York : Springer, 2007.
Series: Ernst Schering Foundation symposium proceedings, 2006/2.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Henry R Bourne
ISBN: 9783540489818 3540489819
OCLC Number: 77258179
Description: xvii, 267 pages : illustrations, portraits.
Contents: G-Proteins and GPCRs: From the Beginning.- Modeling GPCRs.- QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications.- Privileged Structures in GPCRs.- Designing Compound Libraries Targeting GPCRs.- Orphan Seven Transmembrane Receptor Screening.- The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling.- Deorphanization of G-Protein-Coupled Receptors.- Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target.- Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins.- High Content Screening to Monitor G Protein-Coupled Receptor Internalisation.- High-Throughput Lead Finding and Optimisation for GPCR Targets.
Series Title: Ernst Schering Foundation symposium proceedings, 2006/2.
Responsibility: H. Bourne [and others], editors.
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