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Handbook of Lung Cancer and Other Thoracic Malignancies.

Author: Gregory P MD Kalemkerian; Jessica S MD Donington; Elizabeth M MD Gore; Suresh S MD Ramalingam
Publisher: New York : Springer Publishing Company, 2016.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Kalemkerian, Gregory P., MD.
Handbook of Lung Cancer and Other Thoracic Malignancies.
New York : Springer Publishing Company, ©2016
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gregory P MD Kalemkerian; Jessica S MD Donington; Elizabeth M MD Gore; Suresh S MD Ramalingam
ISBN: 9781617052729 1617052728
OCLC Number: 962450306
Notes: Percutaneous Ablative Therapy.
Description: 1 online resource (416 pages)
Contents: Cover; Title; Copyright; Contents; Contributors; Preface; Share Handbook of Lung Cancer and Other Thoracic Malignancies; Chapter 1: Epidemiology and Etiology of Lung Cancer; Incidence and Mortality; Survival; Risk Factors for Lung Cancer; Tobacco and Inhaled Smoke Exposures; Environmental Exposures; Genetic Susceptibility; Chronic Obstructive Pulmonary Disease; Infectious Agents; Summary; Key Points; References; Chapter 2: Biologic Basis of Lung Cancer; Lung Carcinogenesis; Exposure and Susceptibility; Field Carcinogenesis; Lung Development and Carcinogenesis. Molecular Determinants of Histologic SubtypesLung Cancer Genetics; KRAS Mutation; EGFR Mutation; ALK Rearrangement; Resistance to Targeted Therapy; Epigenetics; Methylation; Micro-RNA; Tumor Microenvironment; TGFß Signaling; Epithelial-Mesenchymal Transition; Immune Checkpoints; Key Points; References; Chapter 3: Cellular and Molecular Pathology of Lung Cancer; Introduction; Histologic Subtyping of Lung Cancer; Squamous Cell Carcinoma; Adenocarcinoma; Small Cell Lung Cancer; Immunohistochemistry; Molecular Diversity in NSCLC; Epidermal Growth Factor Receptor; Anaplastic Lymphoma Kinase. Human Epidermal Growth Factor Receptor 2Biomarkers for Immunotherapy; Molecular Diagnostic Assays; Immunohistochemistry; Sanger Sequencing; Reverse Transcription Polymerase Chain Reaction; Fluorescence in Situ Hybridization; Multiplex Hot Spot Mutational Testing; Next-Generation Sequencing; Histologic and Molecular Diagnostic Workflow for NSCLC; Key Points; References; Chapter 4: Lung Cancer Screening; Introduction; Cancer Screening Bias; Chest Radiography for Lung Cancer Screening; Early Studies; The Prostate, Lung, Colorectal, and Ovarian Trial. Computed Tomography (CT) for Lung Cancer ScreeningEarly Studies; The National Lung Screening Trial (NLST); On-Going Studies; CT Screening Recommendations; CT Screening Interpratation Guidelines; Lung Imaging Reporting and Data System (Lung-RADS"!; Prescreening Lung Cancer Risk Assessment; Risks of Lung Cancer Screening; Radiation Exposure; Unnecessary Interventions; Cost; Incidental Findings; Lung Cancer Biomarkers; Micro-RNA; Protein Signatures; Autoantibodies; Biomarker Summary; Conclusion; Key Points; References; Chapter 5: Diagnosis and Staging of Lung Cancer; Introduction. Clinical Features of Lung CancerEvaluation of a Solitary Pulmonary Nodule; Common Symptoms; Diagnosis and Staging; Imaging Studies; Staging Classification; Diagnostic Biopsy; Mediastinal Staging; Histologic Classification and Molecular Markers; Functional Assessment; Key Points; References; Chapter 6: Management of Early Stage Non-Small-Cell Lung Cancer; Introduction; Surgery; Preoperative Assessment; Lobectomy; Sublobar Resection; Adjuvant Therapy; Platinum-Based Adjuvant Therapy; Targeted Adjuvant Therapy; Nonsurgical Therapy; Stereotactic Body Radiation Therapy.

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