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Handbook of neurotoxicity

Author: Richard M Kostrzewa
Publisher: New York, NY : SpringerReference, 2014.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
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Handbook of Neurotoxicity

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Genre/Form: Electronic books
Handbooks and manuals
Handbooks, manuals, etc
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Richard M Kostrzewa
ISBN: 9781461458364 1461458366
OCLC Number: 881315260
Notes: Includes index.
Description: 1 online resource (xxxviii, 2371 pages) : illustrations (some color)
Contents: Neurotoxins: Survey of Selective Neurotoxins.- Necroptosis, a potential therapeutic target for neurological disorders.- Cell System for Identifying Dopaminergic Neurotoxicity.- Microglia: Neuroprotective and Neurodestructive Properties.- 6-Hydroxydopamine Lesioning of Dopamine Neurons in Neonatal and Adult Rats Induces Age-Dependent Consequences.- Dopamine and L-DOPA as Selective Endogenous Neurotoxins.- Nature of DSP-4-Induced Neurotoxicity.- MPTP Neurotoxicity: Actions, Mechanisms and Animal Modeling of Parkinson's disease.- Cocaine as a Neurotoxin.- 76-5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins.- 2'-NH2-MPTP: A Serotonin and Norepinephrine Neurotoxin.- Methamphetamine and MDMA neurotoxicity: Biochemical and molecular mechanisms.- Glutamate as a Neurotoxin.- Domoic acid as a Neurotoxin.- Endogenous Kynurenic acid and Neurotoxicity.- Neurotoxicity in psychostimulant and opiate addiction.- Molecular Mechanism and Effects of Clostridial Neurotoxins.- Botulinum neurotoxins as therapeutics.-Neurotoxic Effects, Mechanisms and Outcome of 192-IgG Saporin.- TRPV1 activators ("vanilloids") as neurotoxins.- Part 2: Dopamine Chemistry & Parkinson Disease.- 6-Hydroxydopamine as preclinical model of Parkinson's disease.- Advances in stem cell research for Parkinson disease.-Alpha synuclein in Parkinson's Disease.- Autophagic pathways and Parkinson disease.- Dopaminergic neurons in Parkinson's disease.- Iron Neurotoxicity in Parkinson's Disease.- Links between paraquat and Parkinson's disease.- Manganese neurotoxicity.- Mechanisms of dopamine oxidation and Parkinson's Disease.- Neuroinflammation and Parkinson's Disease.- Neuromelanin and Parkinson's disease.- Neurotoxicity of 1-methyl1-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a Parkinson's disease model.- N-Methyl-(R) Salsolinol and the enzymes catalyzingits synthesis and metabolism in Parkinson's Disease.- Regulation of DA homeostasis and role of VMAT2 in DA-induced neurodegeneration.- Rotenone as preclinical model compound in Parkinson disease.- Part 3: Glutamate Receptor Agonists & Antagonists.- Concept of Excitotoxicity via Glutamate Receptors.- Role of Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders.- Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disease.- Glutamate Neurotoxicity, Transport and Alternate Splicing of Transporters.- AIDS.- Cancer-mediated neurotoxicity.- Drug Treatments for Alzheimer's Disease: Hopes and Challenges.- Epilepsy.- Excitotoxicity and Amyotrophic Lateral Sclerosis.- Excitotoxicity and axon degeneration.- Excitotoxicity in HIV associated neurocognitive disorders.- Excitotoxicity in the Pathogenesis of Autism.- Glutamate and Neurodegeneration in the Retina.- Glutamate in the Pathogenesis of Gliomas.- Glutamate Neurotoxicity related to Energy Failure.- Glutamategric receptors in Parkinson's disease.- Lead & excitotoxicity.- MS & excitotoxicity.- Neuroprotectants Targeting NMDA Receptor Signaling.- Neuroprotection by Kynurenine Metabolites.- Neuroprotective Strategies in Amyotrophic Lateral Sclerosis: Modulation of Neurotransmittory and Neurotrophic Input to Motor Neurons.- Neurotoxicity and ALS: Insights into Pathogenesis.- Neurotoxicity and Neuroprotection in Spinal Cord.- Neurotoxicity and Stroke.- Neurotoxicity in Huntington Disease.- Neurotoxicity: a complex multistage process involving different mechanisms.- Quinolinate and related excitotoxins: mechanisms of neurotoxicity and disease relevance.- Role of Neurotoxicity in Depression.- Part 4: Neurotrophins: Amyloid-Beta, BDNF and the Mechanism of Neurodegeneration in Alzheimer's Disease.- BDNF V66M polymorphism and brain functions.- Blood brain-derived neurotrophic factor levels and mood disorders.- Neuroprotection in Demyelinating Diseases: the therapeutic potential of the neurotrophins.- Neurotrophic Factors and Ethanol Neurotoxicity.- Neurotrophic factors and NeuroAIDS: a lesson from brain-derived neurotrophic factor.- Neurotrophic therapy for ALS/ MND.- Neurotrophins and p75NTR in axonal regeneration and myelination.- Neurotrophins and pain.- Neutrophin signaling in Cancer.- NGF and immune regulation.- NGF/P75 in cell cycle and tetraploidy.- p75NTR processing and signaling: functional role.- p75NTR-A molecule with multiple functions in amyloid-beta metabolism and neurotoxicity.- Seizures tip the balance of neurotrophin signaling towards neuronal death.- Synthesis, trafficking and release of bdnf.- Trafficking of neurotrophins and their receptors and pathological significance.- Part 5: Diseases and Disorders Relevant to Neurotoxins.- Drug Abuse Neurotoxicity: Alcohol and Nicotine as Developmental Stressors.- Experimental Approach to Alzheimer Disease.- Fusion Models and 'Fusioning'in Parkinsonism: Protection and Restoration by Exercise.- Iron-induced dopaminergic cell death in vivo as a model of Parkinson's disease.- Molecular, cellular and behavioural effects produced by perinatal asphyxia: protection by poly (ADP-ribose) polymerase 1 (PARP-1) inhibition.- MPTP: advances from an evergreen neurotoxin.- Nanomedicines for Nervous System Diseases.- Neurodegenerative aspects of multiple system atrophy.- Neurotoxic Vulnerability Underlying Schizophrenia Spectrum Disorders.- Neurotoxicity of Methamphetamine.- Pathophysiology of obsessive-compulsive disorder: Insights from normal function and neurotoxic effects of drugs, infection and brain injury.- Physical Exercise as Intervention in Parkinsonism.- Protective agents in Parkinson's disease: caffeine and adenosine A2A receptor antagonists.- Stem Cell Therapies for Age Associated Neurodegeneration.- Tardive Dyskinesia: Outcome of antipsychotic treatment and brain damage?.- Pathogenesis of Alzheimer's disease.- Potential therapeutic effects of statins in Alzheimer's disease.
Responsibility: Richard M. Kostrzewa, editor.
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