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Haploidentical transplantation : concepts & clinical application

Author: Stefan O Ciurea; Rupert Handgretinger
Publisher: Cham, Switzerland : Springer, 2018.
Series: Advances and controversies in hematopoietic transplantation and cell therapy.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Haploidentical transplantation.
Cham, Switzerland : Springer, 2018
(OCoLC)970684149
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Stefan O Ciurea; Rupert Handgretinger
ISBN: 9783319543109 3319543105
OCLC Number: 1034985553
Description: 1 online resource (xi, 337 pages) : illustrations (some color).
Contents: Intro; Preface; Contents; 1: Historical Perspective and Current Trends in Haploidentical Transplantation; 1.1 Introduction; 1.2 T-Cell-Depleted HLA-Haploidentical Transplants: Biologic and Clinical Studies; 1.2.1 Strengths; 1.2.2 Drawbacks; 1.3 Today's World: State of the Art in T-Cell-Depleted HLA-ƯHaploidentical Transplants; 1.4 T-Cell-Replete HLA-Haploidentical Transplants; 1.5 Expert Point of View; 1.5.1 The Way Forward for HLA-Haploidentical Transplant: T-Cell-Depleted or T-Cell-Replete?; References; Part I: Graft Manipulation and Methods to Control T-cell Alloreactivity. 2: Toward Safer CD34+ Megadose T-Cell-Depleted Transplants Following Reduced Intensity and Nonmyeloablative Conditioning Regimens2.1 Introduction; 2.2 Overcoming HLA Barriers with T-Cell-Depleted Transplantation; 2.3 Megadose of CD34+ Cells: Regulatory Activity and Overcoming the HLA Barrier; 2.4 Megadose CD34+ Cells Coupled with TCD and Reduced Intensity Conditioning (RIC); 2.5 Combining HLA-Mismatched TCD Megadose BM with Adoptive Transfer of Veto Cells Under RIC; 2.6 Expert Point of View; 2.7 Future Directions. 4.3 Overcoming Leukemia Relapse with Next-Generation Immunotherapy4.3.1 Learning from Animal Models; 4.4 Adoptive Immunotherapy: Translating Lessons to the Clinical Setting in Haploidentical Transplants; 4.5 Expert Point of View; 4.6 Future Directions; References; 5: Haploidentical Transplantation Using Unmanipulated G-CSF-Primed Blood and Marrow as Allografts: Clinical Data and Challenges; 5.1 Introduction; 5.2 Effects of G-CSF on Hematopoietic Graft; 5.3 Establishment of the Beijing Protocol for Haploidentical Transplants.
Series Title: Advances and controversies in hematopoietic transplantation and cell therapy.
Responsibility: Stefan O. Ciurea, Rupert Handgretinger, editors.

Abstract:

In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing  Read more...

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