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|Additional Physical Format:||Print version:
Hedgehog signaling activation in human cancer and its clinical implications.
Dordrecht : Springer, ©2011
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
|ISBN:||9781441984357 1441984356 9781441984340 1441984348|
|Description:||1 online resource (ix, 217 pages) : illustrations|
|Contents:||Chapter 1: Overview of Hedgehog Signaling Pathway; Introduction; Hh Signal Transduction; Lipid Modification and Multimerization of Hh; Heparan Sulfate Proteoglycans Regulate Hh Signaling; Modulation of Pathway Activity by Multiple Hh-Binding Proteins; Ptc Inhibits Smo Catalytically; Regulation of Smo Trafficking and Conformation; Downstream of Smo: G Protein and Cos2/Kif 7-Ci/Gli Signaling Complex; Control of Gli Protein Degradation and Processing; Sufu: A Key Regulator of Mammalian Hh Signaling; Unresolved Questions in Mammalian Hh Signaling; References. Chapter 2: Regulation of the Hedgehog Morphogene Gradient*Introduction; Atypical Biosynthesis of Active Hh Signaling Peptide; Routing of Hh to the Plasma Membrane; Secretion and Release of Lipid-Modified Hh; Hedgehog Spreading: A Dilemma in Motion; Extracellular Gradient Formation by HSPGs; A Similar Spreading Mechanism from Flies to Mice?; Hh Uses Multiple Carriers for Its Travels; Conclusions; References; Chapter 3: Smoothened Signaling Through a G-Protein Effector Network; Introduction; Hedgehog Signal Transduction; Smoothened as a G-Protein-Coupled Receptor. SMO Signaling Through Heterotrimeric G-ProteinsA SMO-Dependent G-Protein Signaling Network; Small-Molecule Modulators of SMO; Future Directions; References; Chapter 4: Kinases and Phosphatases in Hedgehog Signaling; Phosphorylation Events in Hh Signaling; Kinases Regulating the Transcriptional Factor, Ci /Gli; Kinases Mediating the Activation of Smo in Response to Hh; Non-conserved Mechanisms of Regulation by Kinases; Phosphatases in Hh Signaling; Gradient Hh Signaling Activity Is Interpreted by Differential Phosphorylation of the Intracellular Components; References. Chapter 5: Signaling Cross-Talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic CancerIntroduction; KRAS Signaling and PDA; Cross-Talk Between KRAS and Hh Signaling in Cancer; Anticancer Therapeutics Targeting KRAS or Hh Pathway; Conclusion; References; Chapter 6: Hedgehog and Protein Kinase C Signaling; Introduction; Protein Kinase C; Functions of Different PKC Isoforms in Human Cancer; Crosstalk of HH and PKC; Crosstalk of HH and PKC in Development; Crosstalk of HH and PKC in Stem Cells; Crosstalk of HH and PKC in Human Cancer; MEK/ERK Pathway in PKC-Mediated HH Signaling; Summary.|
|Responsibility:||Jingwu Xie, Editor.|