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Heme and Hemoproteins

Author: Francesco Matteis; W Norman Aldridge
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1978.
Series: Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology,, 44.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

The study of the biological effects of foreign chemicals (whether therapeutic drugs or chemicals present at work or in the environment) interests the biologist from a number of different and  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Francesco Matteis; W Norman Aldridge
ISBN: 9783642667633 3642667635 9783642667657 3642667651
OCLC Number: 840293939
Description: 1 online resource.
Contents: 1 The Biosynthesis and Degradation of Heme --
A. Introduction --
B. Structures of Porphyrins and Hemes --
C. Function and Turnover of Hemoproteins --
D. Enzymes of Heme Biosynthesis and Degradation --
E. Conjugation of Bilirubin --
F. Control of Heme and Hemoprotein Biosynthesis --
Abbreviations --
References --
2 Induction of Hepatic Hemoproteins --
A. Introduction --
B. Use of the Term Induction in Studies on Mammalian Tissues --
C. Tryptophan Pyrrolase (Dioxygenase) --
D. Cytochromes of the Endoplasmic Reticulum --
E. Catalase --
F. Mitochondrial Cytochromes --
G. Summary of Conclusions --
Recommended Reviews --
References --
3 Inhibition of Liver Hemoprotein Synthesis --
A. Introduction --
B. Agents Inhibiting Heme Biosynthesis and Hepatic Hemoprotein Synthesis --
C. Conclusions --
Abbreviations --
References --
4 Loss of Liver Cytochrome P-450 Caused by Chemicals. Damage to the Apoprotein and Degradation of the Heme Moiety --
A. Introduction --
B. Loss of Liver Cytochrome P-450 Caused by Chemicals Which Require Metabolic Conversion to Reactive Derivatives --
C. Increased Breakdown of the Heme of Liver Cytochrome P-450 Associated with Lipid Peroxidation --
D. Loss of Liver Cytochrome P-450 Caused by the Administration of Various Metals --
References --
5 Hepatic Porphyrias Caused by 2-Allyl-2-isopropylacetamide, 3,5-Diethoxycarbonyl-1,4-dihydrocollidine, Griseofulvin and Related Compounds --
A. Introduction --
B. The Mechanism of Induction of Porphyria by Drugs --
Abbreviations --
References --
6 Porphyria Caused by Hexachlorobenzene and Other Polyhalogenated Aromatic Hydrocarbons. --
A. Introduction --
B. Properties and Metabolism of Porphyrogenic Polyhalogenated Aromatic Hydrocarbons --
C. Porphyria Caused by Hexachlorobenzene and Other Halogenated Aromatic Hydrocarbons --
D. The Effect of Polyhalogenated Aromatic Hydrocarbons on Heme Metabolism in the Liver --
E. The Mechanism of the Porphyrogenic Action of Polyhalogenated Aromatic Hydrocarbons --
F. General Conclusions --
Abbreviations --
References --
7 The Effect of Chemicals on Hepatic Heme Biosynthesis. Differences in Response to Porphyrin-Inducing Chemicals Between Chick Embryo Liver Cells, the 17-Day-Old Chick Embryo and Other Species. --
A. Introduction --
B. Porphyrin Induction in Chick Embryo Liver Cells --
C. Porphyrin Induction in 17-Day-Old Chick Embryos --
D. Porphyrin Induction in Chickens and Japanese Quail --
E. Differences in Response to Porphyrin-Inducing Drugs in Different Species and Model Test Systems --
Abbreviations --
References --
8 Pharmacogenetics in the Field of Heme Metabolism: Drug Sensitivity in Hereditary Hepatic Porphyria. --
A. Hereditary Hepatic Porphyrias --
B. Precipitation of Hereditary Hepatic Porphyria by Drugs --
C. Experimental Models for the Exacerbation of Hereditary Hepatic Porphyria by Drugs --
D. Common Basis for Induction of Hepatic ALA-Synthetase in Clinical and Experimental Porphyria --
References --
9 The Influence of Hormonal and Nutritional Factors on the Regulation of Liver Heme Biosynthesis. --
A. Introduction --
B. The Influence of Nutritional Factors --
C. The Influence of Hormonal Factors --
References --
10 Effects of Drugs on Bilirubin Metabolism. --
Definition of Certain Abnormalities of Bilirubin Metabolism --
A. Introduction --
B. Normal Bilirubin Metabolism --
C. Drug-Mediated Alterations in Bilirubin Metabolism --
References --
11 Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism. --
A. Biosynthesis of Heme --
B. Effect of Lead on the Heme Biosynthetic Pathway --
C. Toxic Effects of Exposure to Lead --
D. Biological Defense Mechanisms Against Lead --
E. Factors Affecting the Toxic Effects of Lead --
F. Diagnosis of Lead Poisoning --
G. Summary --
Abbreviations --
References --
Author Index.
Series Title: Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology,, 44.
Responsibility: edited by Francesco Matteis, W. Norman Aldridge.

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