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The hERG cardiac potassium channel : structure, function and long QT syndrome

Author: Derek Chadwick; Jamie Goode; Novartis Foundation.
Publisher: Chichester, UK ; Hoboken, NJ : John Wiley & Sons, 2005.
Series: Novartis Foundation symposium, 266.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:
"This book draws together contributions from basic, pharmaceutical and clinical sciences and regulatory authority perspectives aimed at a better understanding of the structure and function of hERG, the molecular basis for compound binding and preferred preclinical test systems."--Jacket.
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Genre/Form: Congresses
Conference papers and proceedings
Congrès
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Derek Chadwick; Jamie Goode; Novartis Foundation.
ISBN: 0470021403 9780470021408
OCLC Number: 56875583
Notes: Based on a symposium.
Description: ix, 297 pages : illustrations ; 24 cm.
Contents: Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart / Gail A. Robertson, Eugenia M.C. Jones and Jinling Wang --
Structure-function studies of the outer mouth and voltage sensor domain of hERG / Gea-Ny Tseng and H. Robert Guy --
Voltage sensor movement in the hERG K channel / David R. Piper, Michael C. Sanguinetti and Martin Tristani-Firouzi --
hERG channel trafficking / Eckhard Ficker, Adrienne Dennis, Yuri Kuryshev, Barbara A. Wible and Arthur M. Brown --
Dynamic control of hERG/IKr by PKA-mediated interactions with 14-3-3 / Anna Kagan and Thomas V. McDonald --
Does hERG coassemble with a [beta] subunit? Evidence for roles of MinK and MiRP1 / Arun Anantharam and Geoffrey W. Abbott --
hERG block, QT liability and sudden cardiac death / Arthur M. Brown --
Structural determinants for high-affinity block of hERG potassium channels / John Mitcheson, Matthew Perry, Phillip Stansfeld, Michael C. Sanguinetti, Harry Witchel and Jules Hancox --
Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs / Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya, John Mitcheson and José A. Sanchez-Chapula --
In silico modelling : pharmacophores and hERG channel models / Maurizio Recanatini, Andrea Cavalli and Matteo Masetti --
The long QT syndrome : a clinical counterpart of hERG mutations / Peter J. Schwartz --
Cellular mechanisms of Torsade de Pointes / Steven Poelzing and David S. Rosenbaum --
Expression and role of hERG channels in cancer cells / Annarosa Arcangeli --
TRIad, foundation for proarrhythmia (triangulation, reverse use dependence and instability) / Luc M. Hondeghem --
Drug-induced QT interval prolongation : regulatory guidance and perspectives on hERG channel studies / Rashmi R Shah.
Series Title: Novartis Foundation symposium, 266.
Responsibility: [editors, Derek J. Chadwick, James Goode].

Abstract:

"This book draws together contributions from basic, pharmaceutical and clinical sciences and regulatory authority perspectives aimed at a better understanding of the structure and function of hERG, the molecular basis for compound binding and preferred preclinical test systems."--Jacket.

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