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Heterogeneity in asthma

Author: Allan R Brasier
Publisher: New York : Springer, 2014.
Series: Advances in experimental medicine and biology, v. 795.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Heterogeneity in asthma.
New York : Springer, [2014]
xiv, 354 pages
(DLC) 17914595
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Allan R Brasier
ISBN: 9781461486039 1461486033 1461486025 9781461486022
OCLC Number: 864682020
Description: 1 online resource (xiv, 354 pages) : illustrations (some color).
Contents: Part I. The Spectrum of Asthma: An Introduction --
Introduction to Asthma and Phenotyping / Regina A. Pillai and William J. Calhoun --
Epidemiology of Asthma: Prevalence and Burden of Disease / Sharon Croisant --
Heterogeneity of Asthma in Society / Rohit Divekar and William J. Calhoun --
Inhaled Environmental Allergens and Toxicants as Determinants of the Asthma Phenotype / Kristin Sokol, Sanjiv Sur and Bill T. Ameredes --
Current Clinical Diagnostic Tests for Asthma / Shiwan Shah and Gulshan Sharma --
Management of Asthma: The Current US and European Guidelines / Ashwini P. Reddy and Meera R. Gupta --
Community-Based Interventions in Asthma / Sharon Petronella Croisant and Lauren Scott --
Heterogeneity of Response to Therapy / William J. Calhoun --
Part II. Genetics and Genomics in Asthma --
Introduction to Genetics and Genomics in Asthma: Genetics of Asthma / Rasika Ann Mathias --
Gene Expression Profiling in Asthma / Joanne Sordillo and Benjamin A. Raby --
Asthma Epigenetics / Muhammad T. Salam --
Part III. Proteomics, Metabolomics, and Systems Biology of Asthma --
Overview / John E. Wiktorowicz --
Metabolomics in Asthma / Bruce A. Luxon --
Proteomic Analysis of the Asthmatic Airway / John E. Wiktorowicz and Mohammad Jamaluddin --
Measurement of the Innate Immune Response in the Airway / Allan R. Brasier and Yingxin Zhao --
Functional Proteomics for the Characterization of Impaired Cellular Responses to Glucocorticoids in Asthma / Konrad Pazdrak and Alexander Kurosky --
Part IV. Modeling Complex Data in Asthma --
Analysis and Predictive Modeling of Asthma Phenotypes / Allan R. Brasier and Hyunsu Ju --
The Role of Visual Analytics in Asthma Phenotyping and Biomarker Discovery / Suresh K. Bhavnani, Justin Drake and Rohit Divekar --
Part V. Biobehavioral Determinants in Asthma --
Central Nervous System Influences in Asthma / Joel N. Kline and Robert M. Rose --
Asthma, Culture, and Cultural Analysis: Continuing Challenges / Mike Fortun, Kim Fortun, Brandon Costelloe-Kuehn, Tahereh Saheb [and 3 others] --
Part VI. Conclusions and Future Directions --
Conclusions and Future Directions / William J. Calhoun and Allan R. Brasier.
Series Title: Advances in experimental medicine and biology, v. 795.
Responsibility: Allan R. Brasier, editors.

Abstract:

This book presents an overview on multidimensional profiling strategies and visualization approaches for phenotyping asthma. It includes cutting-edge methods and protocols and provides step-by-step  Read more...

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