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How trematodes cause limb deformities in amphibians.
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How trematodes cause limb deformities in amphibians.

Author: GF Stopper; L Hecker; RA Franssen; SK Sessions
Edition/Format: Article Article : English
Publication:The Journal of experimental zoology, 2002 Oct 15; 294(3): 252-63
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Other Databases: British Library Serials
Summary:
We used trematode cyst infestation to induce limb deformities in two species of frogs of the genus Rana and compared them to deformities induced by surgical limb bud rotations. The specific deformities produced by both treatments closely resemble those of wild-caught deformed amphibians and are consistent with a known developmental response to disruption of the spatial organization of cells in developing limb buds.  Read more...
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Details

Document Type: Article
All Authors / Contributors: GF Stopper; L Hecker; RA Franssen; SK Sessions
ISSN:0022-104X
OCLC Number: 112549142
Language Note: English
Awards:

Abstract:

We used trematode cyst infestation to induce limb deformities in two species of frogs of the genus Rana and compared them to deformities induced by surgical limb bud rotations. The specific deformities produced by both treatments closely resemble those of wild-caught deformed amphibians and are consistent with a known developmental response to disruption of the spatial organization of cells in developing limb buds. Histological analysis showed that trematode cysts cause massive disruption and abnormal cellular growth involving the limb buds of infected individuals. Our results indicate that trematode cyst infestation causes deformities in frogs by perturbation of the positional relationships of cells in developing limb buds. The crippling effects of cyst-infection on frogs may reflect complex co-evolutionary interactions among trematodes, frogs, and other hosts in the trematode's life cycle.

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