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HPLC method development for pharmaceuticals

Author: Satinder Ahuja; Henrik Rasmussen
Publisher: Amsterdam ; Boston : Elsevier, Academic Press, 2007.
Series: Separation science and technology (San Diego, Calif.), v. 8.
Edition/Format:   eBook : Document : English : 1st edView all editions and formats
Summary:
A definitive reference source of HPLC method development.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
HPLC method development for pharmaceuticals.
Amsterdam ; Boston : Elsevier, Academic Press, 2007
(OCoLC)144220768
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Satinder Ahuja; Henrik Rasmussen
ISBN: 9780080554198 0080554199
OCLC Number: 182555795
Description: 1 online resource (xvii, 513 pages) : illustrations.
Contents: Cover --
CONTENTS --
PREFACE --
CONTRIBUTORS --
Chapter 1. Overview of HPLC Method Development for Pharmaceuticals --
I. Introduction --
II. Theoretical Considerations --
III. HPLC Columns and Column Packings --
IV. Column Selection --
V. Chiral Separations --
VI. Contemporary HPLC --
VII. Hyphenated Methods --
VIII. Sample Preparation --
IX. Instrument Qualification and Software Validation --
X. Pharmaceutical Development --
XI. Drug Discovery --
XII. Early Phase Method Development --
XIII. Late Phase Development --
XIV. In-Process Testing --
XV. Method Development for Biomolecules --
XVI. Method Validation --
XVII. Troubleshooting --
XVIII. Molecularly Imprinted Polymers --
References --
Chapter 2. HPLC Theory --
Abstract --
I. Introduction --
II. Basic Chromatographic Descriptors --
III. Efficiency --
IV. Resolution --
V. Main Components of the Retention Mechanism --
VI. General Column Mass Balance --
VII. Partitioning Model --
VIII. Adsorption Model --
IX. Void Volume Considerations --
X. Thermodynamic Relationships --
XI. Secondary Equilibria --
XII. Salt Effect --
XIII. Effect of Different Counteranions --
XIV. Inclusion of Secondary Equilibria in the Mass Balance --
XV. Conclusions --
References --
Chapter 3. HPLC Columns and Packings --
Abstract --
I. Introduction --
II. Column Chemistry --
III. Speed and Resolution --
IV. Specialty Columns from Nanobore to Preparative Chromatography --
V. Summary --
References --
Chapter 4. Column Characterization and Selection --
Abstract --
I. Introduction --
II. Characteristics of RP-HPLC Columns and Chromatographic Tests --
III. Column Classification and Selection --
IV. Conclusions --
Acknowledgment --
References --
Chapter 5. Chiral Separations --
Abstract --
I. Introduction --
II. Separation of Enantiomers on HPLC Chiral Stationary Phases --
III. Practical Guidelines to Chiral HPLC of Pharmaceuticals --
IV. Conclusions --
References --
Chapter 6. Contemporary Liquid Chromatographic Systems for Method Development --
Abstract --
I. Introduction --
II. Traditional Instrumentation for HPLC Method Development --
III. Contemporary Method Development Systems --
IV. Migrating Methods from HPLC to UPLC --
V. UPLC Applications in Pharmaceutical Analysis --
VI. Summary and Conclusions --
Acknowledgments --
References --
Further Reading --
Chapter 7. Hyphenated Techniques --
Abstract --
I. Introduction and Background --
II. Combined Liquid Chromatography/Mass Spectrometry --
III. Combined Liquid Chromatography/Nuclear Magnetic Resonance Spectroscopy --
IV. Conclusions --
Acknowledgments --
References --
Chapter 8. HPLC Sample Preparation --
Abstract --
I. Introduction --
II. Fundamentals of Extraction and Chemical Equilibrium --
III. Choice of Samples Preparation --
IV. Direct Injection --
V. Liquid-Liquid Extraction --
VI. Solid-Phase Extraction --
VII. Solid Samples --
VIII.
Series Title: Separation science and technology (San Diego, Calif.), v. 8.
Responsibility: edited by Satinder Ahuja, Henrik Rasmussen.

Abstract:

Provides an overview of modern high pressure, or high performance, liquid chromatography (HPLC) method development that addresses various concerns. This work includes a review of the state of the art  Read more...

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Review in Doody's 2008, by Joseph Boullata, PharmD(University of Pennsylvania College of Nursing):"This book is written with pharmaceutical scientists in mind, regardless of their level of experience Read more...

 
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