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Human Drug Metabolism : an Introduction.

Author: Michael Coleman
Publisher: Chichester : John Wiley & Sons, 2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and  Read more...
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Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Michael Coleman
ISBN: 9780470689349 047068934X 1282686534 9781282686533
OCLC Number: 609862961
Description: 1 online resource (362 pages)
Contents: Human Drug Metabolism: An Introduction, Second Edition; Contents; Preface; Preface to First Edition; 1: Introduction; 2: Drug Biotransformational Systems Origins and Aims; 3: How Oxidative Systems Metabolize Substrates; 4: Induction of Cytochrome P450 Systems; 5: Cytochrome P450 Inhibition; 6: Conjugation and Transport Processes; 7: Factors Affecting Drug Metabolism; 8: Role of Metabolism in Drug Toxicity; Appendix A: Methods in Drug Metabolism; Appendix B: Metabolism of Major Illicit Drugs; Appendix C: Examination Techniques. Appendix D: Summary of Major CYP Isoforms and their Substrates, Inhibitors and InducersSuggested Further Reading; Index.

Abstract:

Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and.

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