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Human Fetal Tissue Transplantation

Author: Niranjan Bhattacharya; Phillip Stubblefield
Publisher: Dordrecht : Springer, 2012.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Many diseases earlier considered to be incurable are now being treated with modern innovations involving fetal tissue transplants and stem cells derived from fetal tissues. Fetal tissues are the richest source of fetal stem cells as well as other varying states of differentiated cells and support or stromal cells. The activity of such stem cells is at their peak provided they are given the correct niche. Stem cells,  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Bhattacharya, Niranjan.
Human Fetal Tissue Transplantation.
Dordrecht : Springer, ©2012
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Niranjan Bhattacharya; Phillip Stubblefield
ISBN: 9781447141716 1447141717
OCLC Number: 828794667
Notes: Fibroblasts' Responses to Growth Factors.
Description: 1 online resource (466 pages)
Contents: Human Fetal Tissue Transplantation; Copyright; Dedication; Preface; Preamble; References; Acknowledgments; Contents; Contributors; Introduction; Part I: The Ideas Behind This Book; 1: Alternatives of Human Organ/Tissue Transplantation; Introduction; Xenotransplantation; Problem of Disease Transmission in Xenotransplantation; Success of Xenotransplantation; Potential Future Animal Organ Donors; Immunological Problems; Ethicality of Xenotransplant Procedures; Looking Further into the Future; Stem Cell Transplantation: To Combat End-State Degeneration of an Important Organ; Embryonal Stem Cell. Cord Blood Stem Cell UseUse of Clone Technology for Creation of Specific Cells/Organs Solely for Transplantation Purpose; The Advantages of Cloning; Clone and Transplant Solution; 3D Tissue Organ Culture; Artificial Organ Support for End-State Organ Failure Waiting for the Transplant; References; 2: Fetomaternal Cell Trafficking: A Window into the Long-Term Health Effects of Treating Disease with Fetal Cell/Tissue Tra ... ; Introduction; Maternal Tolerance of Fetal Tissue; Microchimerism and Transplant Tolerance; Microchimerism and Maternal Illness; Experience with Fetal Tissue Transplants. An Illustrative CaseDiscussion; Conclusion and Suggestions for the Future; References; Part II: Basic Science and the Unique Aspect of Fetal Growth and Maturation; 3: Embryology of Fetal Tissue; Basic Preimplantation Embryology; The Hemangioblast; Growth and Maturation of Fetal Tissue; Hemopoietic Tissue; The Adult Hemangioblast; Immune Privileges of Growing Fetal Tissue; Maternal-Fetal Tolerance; Stem Cells and Their Niche in Fetal Tissue; Fetal Liver; Fetal Lung; Fetal Aorta; Cytokines in Fetal Tissue; Erythropoietin in the Fetus; Umbilical Cord Serum Cytokines. Fetal and Adult Tissue Interaction in Health and DiseaseFetal Tissue Transplantation; Fetal Microchimerism in Health; Fetal Microchimerism in Abnormal Pregnancy; Fetal Microchimerism in Malignant Disease; The Role of Fetal Microchimerism in Autoimmune Disease; Maternal Microchimerism in the Fetus; References; 4: Three-Dimensional Culture of Fetal Mouse, Rat, and Porcine Hepatocytes; Introduction; General Experimental Protocols; Fetal Mouse Hepatocytes: In Vitro and In Vivo Studies; 3D Culture Using PLLA Scaffolds Versus 2D Monolayer Culture. Implantation of Cell-Loaded 3D Scaffolds into the MesenteryFetal Rat Hepatocytes: In Vitro and In Vivo Studies; 3D Culture Using PLLA Scaffolds Versus 2D Monolayer Culture; Implantation of Cell-Loaded 3D Hyaluronic Acid Scaffolds into the Mesentery; Fetal Porcine Hepatocytes: In Vitro Study; General Discussion and Future Perspectives; References; 5: Response of Fetal and Adult Cells to Growth Factors; Introduction; Differences in Wound Repair Between Fetuses and Adults: Environmental or Intrinsic?; Growth Factors; PDGFs; TGF- b s; EGF Family; FGFs; IGFs; VEGFs.

Abstract:

Many diseases earlier considered to be incurable are now being treated with modern innovations involving fetal tissue transplants and stem cells derived from fetal tissues. Fetal tissues are the richest source of fetal stem cells as well as other varying states of differentiated cells and support or stromal cells. The activity of such stem cells is at their peak provided they are given the correct niche. Stem cells, as we know, are immortal cells with the capacity to regenerate into any kind of differentiated cell as per niche-guidance. As such, fetal tissues have the potential capacity to men.

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Linked Data


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