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|Additional Physical Format:||Print version:
Human Fetal Tissue Transplantation.
Dordrecht : Springer, ©2012
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Niranjan Bhattacharya; Phillip Stubblefield
|Notes:||Fibroblasts' Responses to Growth Factors.|
|Description:||1 online resource (466 pages)|
|Contents:||Human Fetal Tissue Transplantation; Copyright; Dedication; Preface; Preamble; References; Acknowledgments; Contents; Contributors; Introduction; Part I: The Ideas Behind This Book; 1: Alternatives of Human Organ/Tissue Transplantation; Introduction; Xenotransplantation; Problem of Disease Transmission in Xenotransplantation; Success of Xenotransplantation; Potential Future Animal Organ Donors; Immunological Problems; Ethicality of Xenotransplant Procedures; Looking Further into the Future; Stem Cell Transplantation: To Combat End-State Degeneration of an Important Organ; Embryonal Stem Cell. Cord Blood Stem Cell UseUse of Clone Technology for Creation of Specific Cells/Organs Solely for Transplantation Purpose; The Advantages of Cloning; Clone and Transplant Solution; 3D Tissue Organ Culture; Artificial Organ Support for End-State Organ Failure Waiting for the Transplant; References; 2: Fetomaternal Cell Trafficking: A Window into the Long-Term Health Effects of Treating Disease with Fetal Cell/Tissue Tra ... ; Introduction; Maternal Tolerance of Fetal Tissue; Microchimerism and Transplant Tolerance; Microchimerism and Maternal Illness; Experience with Fetal Tissue Transplants. An Illustrative CaseDiscussion; Conclusion and Suggestions for the Future; References; Part II: Basic Science and the Unique Aspect of Fetal Growth and Maturation; 3: Embryology of Fetal Tissue; Basic Preimplantation Embryology; The Hemangioblast; Growth and Maturation of Fetal Tissue; Hemopoietic Tissue; The Adult Hemangioblast; Immune Privileges of Growing Fetal Tissue; Maternal-Fetal Tolerance; Stem Cells and Their Niche in Fetal Tissue; Fetal Liver; Fetal Lung; Fetal Aorta; Cytokines in Fetal Tissue; Erythropoietin in the Fetus; Umbilical Cord Serum Cytokines. Fetal and Adult Tissue Interaction in Health and DiseaseFetal Tissue Transplantation; Fetal Microchimerism in Health; Fetal Microchimerism in Abnormal Pregnancy; Fetal Microchimerism in Malignant Disease; The Role of Fetal Microchimerism in Autoimmune Disease; Maternal Microchimerism in the Fetus; References; 4: Three-Dimensional Culture of Fetal Mouse, Rat, and Porcine Hepatocytes; Introduction; General Experimental Protocols; Fetal Mouse Hepatocytes: In Vitro and In Vivo Studies; 3D Culture Using PLLA Scaffolds Versus 2D Monolayer Culture. Implantation of Cell-Loaded 3D Scaffolds into the MesenteryFetal Rat Hepatocytes: In Vitro and In Vivo Studies; 3D Culture Using PLLA Scaffolds Versus 2D Monolayer Culture; Implantation of Cell-Loaded 3D Hyaluronic Acid Scaffolds into the Mesentery; Fetal Porcine Hepatocytes: In Vitro Study; General Discussion and Future Perspectives; References; 5: Response of Fetal and Adult Cells to Growth Factors; Introduction; Differences in Wound Repair Between Fetuses and Adults: Environmental or Intrinsic?; Growth Factors; PDGFs; TGF- b s; EGF Family; FGFs; IGFs; VEGFs.|