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Human herpesvirus-6 : general virology, epidemiology and clinical pathology

Author: G R F Krueger; D V Ablashi
Publisher: Amsterdam ; Boston : Elsevier, ©2006.
Series: Perspectives in medical virology, v. 12.
Edition/Format:   eBook : Document : English : 2nd edView all editions and formats
Summary:
The most comprehensive review available of all aspects of HHV-6 combining basic and clinical science.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Human herpesvirus-6.
Amsterdam ; Boston : Elsevier, ©2006
(DLC) 2006042524
(OCoLC)63136285
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: G R F Krueger; D V Ablashi
ISBN: 008046128X 9780080461281 0444520635 9780444520630
OCLC Number: 77272797
Notes: Ablashi's name appears first on the earlier edition.
Description: 1 online resource (xvi, 376 pages) : illustrations (some color).
Contents: Foreword / Robert C. Gallo --
Foreword / Ronald Glaser, Marshall V. Williams --
Preface / Gerhard R.F. Krueger, Dharam V. Ablashi --
Discovery and Classification of Human Herpesvirus-6 (HHV-6) / Dharam V. Ablashi --
Ultrastructure and Assembly of Human Herpesvirus-6 (HHV-6) / Z. Hong Zhou, James K. Stoops, Gerhard R.F. Krueger --
HHV-6 Genome: Similar and Different / U.A. Gompels, F.C. Kasolo --
Proteins of HHV-6 / Yasuko Mori --
Biological Features of HHV-6 / Lorenzo Dagna, Fabio Santoro, Paolo Lusso --
Strain Variants of HHV-6 / Dharam V. Ablashi --
Serologic Testing for Acute and Chronic Infection / Henri Agut, Agnes Gautheret-Dejean --
Molecular Testing for HHV-6 Infection / Stephen Dewhurst, Birgit Bradel-Tretheway --
Epidemiology of HHV6 / Caroline Breese Hall --
Pathologic Features of HHV-6 Disease / Gerhard R.F. Krueger, Brigitte Schneider --
Systemic Reactions to HHV-6 Infection / Vincent Descamps, Emmanuel Mahe, Sylvie Ranger-Rogez --
HHV-6 and the Integument / Tetsushi Yoshikawa --
HHV-6 and the Respiratory System / Sebastian M. Schmidt, Helga Wiersbitzky, Siegfried K.W. Wiersbitzky --
HHV-6 and the Lympho-Hematopoietic System / Sylvie Ranger-Rogez, Aurelie Lacroix, François Denis, Dominique Bordessoule --
Human Herpesvirus-6 and the Cellular Immune System / Judith A. Britz --
HHV-6 and the Central Nervous System / Samantha S. Soldan, Andrew D. Goodman, Steven Jacobson --
HHV-6 and the Cardiovascular System / Satoki Fukae, Naoto Ashizawa --
HHV-6 in Cardiovascular Pathology / L. Maximilian Buja --
HHV-6, the Liver and the Gastrointestinal Tract / Tetsushi Yoshikawa --
HHV-6 in Chronic Fatigue Syndrome / Daniel Peterson, Lisa Atwell --
HHV-6 and HIV-1 Infection / Paolo Lusso --
Human Herpesvirus-6 Infection in Solid Organ and Stem Cell Transplant Recipients / P. Ljungman, N. Singh --
Therapeutic Approaches to HHV-6 Infection / Lieve Naesens, Leen De Bolle, Erik De Clercq --
Animal Models / Claude P. Genain --
Computational Simulation of HHV-6 Infection / Guanyu Wang, Gerhard R.F. Krueger --
Experimental Therapeutic Approaches. Cover --
Contents --
Foreword by Robert Gallo --
Foreword by Ronald Glaser and Marshall Williams --
Preface --
Part I: General Virology --
Discovery and Classification of Human Herpesvirus-6 (HHV-6) --
Discovery --
Nomenclature and classification --
References --
Ultrastructure and Assembly of Human Herpesvirus-6 (HHV-6) --
Introduction --
Herpesvirus-6 assembly and maturation --
Three-dimensional structure of HHV-6 capsid --
Comparision of the HHV-6 cappsid structure with those of other human herpesviruses --
Conclusion --
References --
HHV-6 Genome: Similar and Different --
Genome classification and biology --
Genomes, cellular tropism and laboratory culture --
Genome structure and repetitive sequence --
Genome rearrangements and relationship to other herpesviruses --
Genome composition and general molecular biology --
Herpesvirus conserved and HHV-6-specific genes --
Genomes and HHV-6 strains --
Acknowledgements --
References --
Proteins of HHV-6 --
Introduction --
IE proteins --
U16/U17 --
U53, proteinase --
U69, kinase --
Cellular homologues --
U94, AAV-2 rep homologue --
Envelope glycoproteins --
U39, gB --
U48 and U82, gH and gL --
U100, gQ --
U47, gO --
U11 --
U14 --
U27 --
Perspective --
References --
Biological Features of HHV-6 --
Introduction --
HHV-6 cellular receptor --
Species specificity --
Cellular tropism of HHV-6 --
Biological effects of HHV-6 on the host cell --
References --
Part II: Diagnosis and Epidemiology --
Strain Variants of HHV-6 --
Introduction --
Epidemiology --
Molecular biology --
Biological aspects of variants A and B --
Reactivity of monoclonal antibodies to HHV-6 variants A and B --
Disease associations of HHV-6A and -6B variants --
Concluding remarks --
References --
Serologic Testing for Acute and Chronic Infection --
Introduction --
Serologic assays --
Serologic findings --
Pending questions and perspectives --
Acknowledgments --
References --
Molecular Testing for HHV-6 Infection --
Introduction --
Primary infection: characteristics and diagnostic considerations --
PCR analysis of cell-free body fluids --
Reverse transcription PCR analysis --
Quantitative PCR analysis of HHV-6 DNA in PBMC or blood --
Detection of virus variants --
Other assay approaches --
Future assay methods --
PCR-based assays: general considerations and molecular underpinnings --
Commercially available tests --
General considerations for current molecular assays --
References --
Epidemiology of HHV6 --
The epidemiology of roseola from historical observations --
Seroepidemiologic studies of HHV6 infection --
Acquisition of HHV6 infection during childhood --
Acquisition of HHV6 infection according to variant --
Factors affecting acquisition of HHV6 infection --
Mode of transmission --
Incubation period --
Summary --
References --
Part III: Clinical Pathology --
Pathologic Features of HHV-6 Disease --
Introduction --
Cell and tissue tropism and strain differences --
General cellular pathology of HHV-6 infection --
Primary infection --
Reactivation and endogenous reinfection --
Conclusions --
References --
Systemic Reactions to HHV &
Series Title: Perspectives in medical virology, v. 12.
Responsibility: editors, Gerhard Krueger, Dharam Ablashi.

Abstract:

Presents a comprehensive review of Human Herpesvirus-6 (HHV-6) that infects up to 90% of the world's population and can cause potentially life-threatening diseases. This book describes the etiology  Read more...

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