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Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success Titelvorschau
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Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success

Verfasser/in: Stuart LeGrice; Matthias Götte
Verlag: New York, NY : Springer, 2013.
Ausgabe/Format   E-Book : Dokument : EnglischAlle Ausgaben und Formate anzeigen
Datenbank:WorldCat
Zusammenfassung:
The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in  Weiterlesen…
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Gattung/Form: Electronic books
Medientyp: Dokument, Internetquelle
Dokumenttyp: Internet-Ressource, Computer-Datei
Alle Autoren: Stuart LeGrice; Matthias Götte
ISBN: 9781461472919 1461472911 1461472903 9781461472902
OCLC-Nummer: 856550154
Anmerkungen: Includes index.
Beschreibung: 1 online resource (x, 361 pages) : illustrations
Inhalt: Development of the First AIDS Drugs: AZT and Other Dideoxynueosides / Robert Yarchoan, Hiroaki Mitsuya --
Part I: Structure and Function of HIV RT. Proviral DNA Synthesis in HIV: Background / Dorota Piekna-Przybylska Ph. D., Robert A. Bambara Ph. D. --
The RNase H Domain: Structure, Function and Mechanism / Marcin Nowotny, Małgorzata Figiel --
Conformational Dynamics of Reverse Transcription / Stuart F.J. LeGrice --
Part II: Mechanism of Action of Approved RT Inhibitors. Nucleoside RT Inhibitors: Structural and Molecular Biology / Gaofei Lu, Antonio J. Acosta-Hoyos, Walter A. Scott --
Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) / Kalyan Das Ph. D., Eddy Arnold Ph. D., Stephen H. Hughes Ph. D. --
Part III: Alternative Strategies to Interfere with the Function of HIV RT. Ribonuclease H Inhibitors: Structural and Molecular Biology / Jason W. Rausch --
Targeting Small Molecules and Peptides to the p66-p51 Reverse Transcriptase Interface / Daouda Abba Moussa, Audrey Agopian, Gilles Divita --
Targeting RT Translocation / Gregory L. Beilhartz, Brian J. Scarth, Matthias Götte --
tRNA Primer Sequestration as an Antiviral Strategy / Christopher P. Jones, Karin Musier-Forsyth --
Part IV: HIV Genetic Variability and the Problem of Drug Resistance. HIV Reverse Transcriptase Fidelity, Clade Diversity, and Acquisition of Drug Resistance / Luis Menéndez-Arias --
APOBECs and Their Role in Proviral DNA Synthesis / John S. Albin, Reuben S. Harris --
Role of RNase H Activity in NRTI/NNRTI Drug Resistance / Gilda Tachedjian B. Sc. (Hons), Ph. D., Nicolas Sluis-Cremer B. Sc. (Hons), Ph. D. --
HIV Population Dynamics / Mary Kearney, John Coffin --
Part V: Prevention and Future Approaches. RT Inhibitors as Microbicides / Jan Balzarini.
Verfasserangabe: Stuart LeGrice, Matthias Gotte.
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Abstract:

This book covers coordination of RT-associated DNA polymerase and ribonuclease H activities, mechanisms of action and perspectives on NRTIs and NNRTIs, strategies for targeting the RT enzyme and  Weiterlesen…

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