skip to content
Human Insulin : Clinical Pharmacological Studies in Normal Man Preview this item
ClosePreview this item
Checking...

Human Insulin : Clinical Pharmacological Studies in Normal Man

Author: D R Owens
Publisher: Dordrecht : Springer Netherlands, 1986.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i)  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: D R Owens
ISBN: 9789400941618 9400941617
OCLC Number: 851377627
Description: 1 online resource (312 pages)
Contents: 1 Introduction --
1.1 Historical introduction to diabetes and its treatment --
1.2 The evolution of insulin --
2 Objectives of investigations --
3 Investigational procedures --
3.1 Clinical: Subjects, Materials, Methods --
3.2 Laboratory methods --
4 Clinical-pharmacological studies --
4.1 'Short-acting' insulin preprations --
4.2 Insulin preparations with prolonged effect --
4.3 Factors influencing subcutaneous absorption of human insulin --
5 Summary --
Acknowledgements.
Responsibility: by D.R. Owens.

Abstract:

Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(2)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/851377627> # Human Insulin : Clinical Pharmacological Studies in Normal Man
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
   library:oclcnum "851377627" ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/836624217#Place/dordrecht> ; # Dordrecht
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/ne> ;
   schema:about <http://id.worldcat.org/fast/892147> ; # Diabetes
   schema:about <http://dewey.info/class/616.46/e23/> ;
   schema:about <http://id.worldcat.org/fast/1014893> ; # Medicine
   schema:about <http://dewey.info/class/616.462/e23/> ;
   schema:bookFormat schema:EBook ;
   schema:creator <http://viaf.org/viaf/21147146> ; # D. R. Owens
   schema:datePublished "1986" ;
   schema:description "1 Introduction -- 1.1 Historical introduction to diabetes and its treatment -- 1.2 The evolution of insulin -- 2 Objectives of investigations -- 3 Investigational procedures -- 3.1 Clinical: Subjects, Materials, Methods -- 3.2 Laboratory methods -- 4 Clinical-pharmacological studies -- 4.1 'Short-acting' insulin preprations -- 4.2 Insulin preparations with prolonged effect -- 4.3 Factors influencing subcutaneous absorption of human insulin -- 5 Summary -- Acknowledgements."@en ;
   schema:description "Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness."@en ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/836624217> ;
   schema:genre "Electronic books"@en ;
   schema:inLanguage "en" ;
   schema:isSimilarTo <http://worldcat.org/entity/work/data/836624217#CreativeWork/> ;
   schema:name "Human Insulin : Clinical Pharmacological Studies in Normal Man"@en ;
   schema:productID "851377627" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/851377627#PublicationEvent/dordrecht_springer_netherlands_1986> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/836624217#Agent/springer_netherlands> ; # Springer Netherlands
   schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=3108369> ;
   schema:url <http://dx.doi.org/10.1007/978-94-009-4161-8> ;
   schema:url <http://link.springer.com/10.1007/978-94-009-4161-8> ;
   schema:workExample <http://worldcat.org/isbn/9789400941618> ;
   schema:workExample <http://dx.doi.org/10.1007/978-94-009-4161-8> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/851377627> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/836624217#Agent/springer_netherlands> # Springer Netherlands
    a bgn:Agent ;
   schema:name "Springer Netherlands" ;
    .

<http://id.worldcat.org/fast/1014893> # Medicine
    a schema:Intangible ;
   schema:name "Medicine"@en ;
    .

<http://id.worldcat.org/fast/892147> # Diabetes
    a schema:Intangible ;
   schema:name "Diabetes"@en ;
    .

<http://link.springer.com/10.1007/978-94-009-4161-8>
   rdfs:comment "from Springer" ;
   rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://viaf.org/viaf/21147146> # D. R. Owens
    a schema:Person ;
   schema:familyName "Owens" ;
   schema:givenName "D. R." ;
   schema:name "D. R. Owens" ;
    .

<http://worldcat.org/entity/work/data/836624217#CreativeWork/>
    a schema:CreativeWork ;
   schema:description "Print version:" ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/851377627> ; # Human Insulin : Clinical Pharmacological Studies in Normal Man
    .

<http://worldcat.org/isbn/9789400941618>
    a schema:ProductModel ;
   schema:isbn "9400941617" ;
   schema:isbn "9789400941618" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.