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Human retroviruses

Author: Bryan Cullen
Publisher: Oxford ; New York : IRL Press at Oxford University Press, ©1993.
Series: Frontiers in molecular biology, 1.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

Provides a detailed and current overview of the molecular biology of human retroviruses, the most high-profile of which is HIV at the moment. This book aims to cover current research into this  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Bryan Cullen
ISBN: 0199633827 9780199633821 0199633835 9780199633838
OCLC Number: 27147658
Description: xvi, 220 pages : illustrations ; 25 cm.
Contents: Introduction to human retroviruses / Bryan R. Cullen --
Retroviral replication cycle --
Retroviral taxonomy --
Biological and molecular basis for cell tropism in HIV / Vicente Planelles, Qi-Xiang Li and Irvin S.Y. Chen --
Genetic variation of HIV --
Species specificity of HIV --
Tissue distribution of HIV --
CD4 glycoprotein is the major receptor for HIV --
Structure of the HIV envelope glycoprotein --
Tropism of the AIDS virus: historical perspective --
V3 loop as a determinant of tropism --
Envelope regions other than V3 may be involved in tropism --
Regions other than envelope may also control tropism --
Tropism for other cell types --
Mechanisms --
Role of cellular transcription factors in the regulation of human immunodeficiency virus gene expression / Gary J. Nabel --
RNA polymerases and associated transcription factors --
Transcriptional regulatory proteins and the HIV promoter --
Inducible gene expression and the HIV enhancer --
Negative regulation of the HIV enhancer --
NF-kB family of transcriptional activators --
Regulation of NF-kB by IkB. (cont) Anti-oxidants and the regulation of HIV transcription --
Macrophage regulation of HIV expression --
Transcriptional regulation of HIV-2 --
Tat trans-activator / B. Matija Peterlin [and others] --
Tat trans-activator --
Trans-activation response element, TAR --
Mechanisms of trans-activation by TAT --
Tat and the HIV life cycle --
Other effects of Tat --
Post-transcriptional regulation of human retroviral gene expression / Tristram G. Parslow --
Alternative splicing of retroviral RNAs --
Post-transcriptional trans-activation of complex retroviruses --
Translation of retroviral mRNAs --
Potential targets for antiretroviral therapy --
Auxiliary proteins of the primate immunodeficiency viruses / James S. Gibbs and Ronald C. Desrosiers --
vif --
vpr --
vpx --
vpu --
nef --
Molecular biology of human T-cell leukemia viruses / Scott D. Gitlin [and others] --
HTLV genome structure --
Transformation --
Epidemiology --
HTLV-associated diseases --
Tax structure and functional domains --
Rex --
P21(x-III) --
Transcriptional regulation of HTLV gene expression. (cont) Tax trans-activation of cellular genes --
Extracellular cytokine effects of Tax --
Molecular biology of the human spumavirus / Rolf M. Flugel --
Morphological and virological properties of spumaviruses --
Overview of the replication cycle of HSRV in comparison with other retroviruses --
Genetic structure of HSRV is complex --
Transcriptional pattern of the HSRV genome is complex --
Bel 1 is the HSRV transcriptional trans-activator --
HSRV LTR is unusually long and contains different DNA response elements for the trans-activator Bel 1 --
Is Bel 3 a spumaviral superantigen? --
HSRV-specific detection systems --
Sero-epidemiological studies on prevalence of HSRV antibodies --
Neuropathogenicity of HSRV genes in transgenic mice.
Series Title: Frontiers in molecular biology, 1.
Responsibility: edited by Bryan R. Cullen.
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'The book is introduced by an excellent chapter by Cullen himself on retrovirus history, taxonomy and replication ... all chapters are well written and ... well presented and well balanced ... very Read more...

 
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