skip to content
Hyaluronic acid : preparation, properties, application in biology and medicine Preview this item
ClosePreview this item
Checking...

Hyaluronic acid : preparation, properties, application in biology and medicine

Author: Vladimir N Khabarov; Petr Ya Boykov; Mikhail A Selyanin
Publisher: Chichester, West Sussex : John Wiley & Sons, Ltd., 2015.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic Acid: Production, Properties, Application inBiology and Medicine  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Khabarov, V.N. (Vladimir N.).
Hyaluronic acid.
Chichester, West Sussex : John Wiley & Sons, Inc., 2015
(DLC) 2014038400
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Vladimir N Khabarov; Petr Ya Boykov; Mikhail A Selyanin
ISBN: 9781118695951 111869595X 9781118695937 1118695933 1118633792 9781118633793
OCLC Number: 893202820
Description: 1 online resource
Contents: Foreword xi Introduction xiii 1 The History of Hyaluronic Acid Discovery, Foundational Research and Initial Use 1 1.1 Discovery 1 1.2 Foundational Research 2 1.3 Initial Medical Applications 3 1.4 Sources of Hyaluronan 4 1.5 Current Medical Study and Use 6 1.6 Impact and Future Directions 7 References 7 2 The Biological Role of Hyaluronic Acid 9 2.1 Hyaluronic Acid Phylogenesis 9 2.1.1 Polysaccharide Structure and the Problems of Phylogenesis 13 2.1.2 Physico-Chemical and Functional Differences of Polysaccharides 18 2.1.3 Biochemical Features of Hyaluronic Acid and Other Glycosaminoglycans 20 2.2 Functions of Hyaluronan in Human Ontogenesis 22 2.2.1 Role of Hyaluronic Acid in Fertilization 22 2.2.2 Hyaluronan and Other Glucosaminoglycans in Cell Division, Migration and Differentiation 25 2.2.3 Hyaluronic Acid and Sulfated Glycosaminoglycans in Maintaining a Differentiated Status of Cells 33 2.2.4 Hyaluronan and Induction of Cellular Cycles for Differentiated Cells 35 2.2.5 The Source of Hyaluronic Acid s Functional Properties and the Dynamics of its Synthesis and Degradation 44 2.2.6 The Rules of Biopolymer Functional Cleavage 52 2.3 Hyaluronan Signalling Systems 53 2.4 Hyaluronan Functions in the Extracellular Matrix 59 2.4.1 Extracellular Space 60 2.4.2 Composition and Functioning of the Extracellular Matrix 60 2.4.3 The Role of Hyaluronan in Transportation of Substances through the Extracellular Matrix: Diffusion, Osmosis, Electro-Osmosis and Vesicular Transportation 63 2.4.4 Hyaluronan in the Extracellular Matrix of Different Connective Tissues 65 References 67 3 Methods of Hyaluronic Acid Production 77 3.1 Hyaluronan Sources and Extraction 77 3.1.1 Hyaluronan Production from Animal Sources: General Methods 77 3.1.2 Hyaluronan Purification 78 3.1.3 The Chemical Production of Hyaluronan from Chicken Combs 81 3.1.4 HA Production for Ophthalmology 82 3.2 Bacterial Methods of Hyaluronic Acid Production 84 3.3 Hyaluronan Destruction during Production, Storage and Sterilization 85 3.4 Enzymatic Destruction of Hyaluronan 86 3.4.1 Hyaluronidase Classification 86 3.4.2 Properties and Functions of Hyaluronidases 87 3.5 Non-Enzymatic Destruction of Hyaluronan 88 3.5.1 Acid-Base Hydrolysis of Hyaluronan 88 3.5.2 Oxidation-Reduction Depolymerization of Hyaluronan 88 3.6 Quality of Hyaluronan Commercial Products of Animal and Bacterial Origin 89 References 92 4 Molecular and Supramolecular Structure of Hyaluronic Acid 97 4.1 Primary Structure of Hyaluronic Acid 97 4.2 Structure of Hyaluronan in Solution 101 4.3 Rheological Properties of Hyaluronic Acid 104 References 116 5 Chemical Modifications, Solid Phase, Radio-Chemical and Enzymatic Transformations of Hyaluronic Acid 121 5.1 Main Characteristics of Cross-Linked Hydrogels 122 5.2 Methods of Hyaluronic Acid Cross-Linking 124 5.2.1 Cross-Linking with Carbodiimides 124 5.2.2 Cross-Linking with Aldehydes 126 5.2.3 Cross-Linking with Divinylsulfone 126 5.2.4 Cross-Linking by the Ions of Polyvalent Metals 127 5.2.5 Cross-Linking with Epoxides 127 5.2.6 Photo-Cross-Linking 128 5.2.7 Solid-State Cross-Linking under High Pressure and Shear Deformation (Solid-State Reactive Blending: SSRB) 130 5.3 Radiochemical Transformations (Radiolysis) of Hyaluronan Aqueous Solutions 134 References 137 6 Medical Applications of Hyaluronan 143 6.1 Hyaluronan and Aesthetic Medicine 143 6.1.1 Intradermal Hyaluronan-Based Microimplants 143 6.1.2 Cross-Linking of Hyaluronan into a Three-Dimensional Network 144 6.1.3 Hyaluronic Acid in Injection Cosmetology (Biorevitalization) 150 6.1.4 Molecular Weight of Hyaluronan in Biorevitalization Products 151 6.1.5 Antioxidant Efficiency of Hyaluronan and other Biologically Active Compounds as Potential Products for Aesthetic Medicine 154 6.1.6 Bio-Repairants as a New Class of Injectable Products Based on Hyaluronic Acid Modified with Low Molecular Weight Bio-Regulators 161 6.2 Hyaluronan in Arthrology 170 6.3 Hyaluronan in Ophthalmology 176 6.4 Hyaluronan in Oncology 176 6.5 The Role of Hyaluronan in Healing Wounds 183 6.6 Hyaluronan in Immunology 186 References 186 Conclusion 193 Index 195
Responsibility: V.N. Khabarov, P. Ya. Boykov and M.A. Selyanin ; translated from the Russian by scientific editor Dr. F. Polyak.

Abstract:

Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration.  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/893202820> # Hyaluronic acid : preparation, properties, application in biology and medicine
    a schema:Book, schema:MediaObject, schema:CreativeWork ;
    bgn:translationOfWork <http://www.worldcat.org/title/-/oclc/893202820#CreativeWork/unidentifiedOriginalWork> ;
    library:oclcnum "893202820" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/enk> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/2064860360#Topic/organic_acids> ; # Organic acids
    schema:about <http://dewey.info/class/612.015782/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/2064860360#Topic/science_life_sciences_human_anatomy_&_physiology> ; # SCIENCE--Life Sciences--Human Anatomy & Physiology
    schema:about <http://experiment.worldcat.org/entity/work/data/2064860360#Topic/hyaluronic_acid> ; # Hyaluronic acid
    schema:about <http://experiment.worldcat.org/entity/work/data/2064860360#Topic/medical_physiology> ; # MEDICAL--Physiology
    schema:bookFormat schema:EBook ;
    schema:contributor <http://experiment.worldcat.org/entity/work/data/2064860360#Person/selyanin_mikhail_a> ; # Mikhail A. Selyanin
    schema:contributor <http://experiment.worldcat.org/entity/work/data/2064860360#Person/boykov_petr_ya> ; # Petr Ya Boykov
    schema:creator <http://experiment.worldcat.org/entity/work/data/2064860360#Person/khabarov_vladimir_n> ; # Vladimir N. Khabarov
    schema:datePublished "2015" ;
    schema:description "Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid innature, in particular in the human body. The chapter starts fromthe phylogenesis of hyaluronic acid, then describes hyaluronanfunctions in human ontogenesis and especially the role whichhyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purifyhyaluronic acid, including the analytical means for assessingquality of the finished product. Chapter 4 discusses the structureand rheological properties of hyaluronic acid considering effectson conformation and biological properties related to molecularweight. In Chapter 5, the physical and chemical methods formodifying the structure of hyaluronan are discussed includingcross-linking using bi-functional reagents, solid-phasemodification and effects of the combined action of high pressuresand shift deformation. The final chapter focuses on the productsderived from hyaluronic acid, including therapeutics composed ofmodified hyaluronan conjugated to vitamins, amino acids andoligo-peptides. The biological roles and medical applications ofthis polysaccharide have been extensively studied and this bookprovides a wealth of scientific data demonstrating the criticalrole of hyaluronic acid and its promise as a multifacetedbio-macromolecule. Approaching hyaluronic acid from multiple angles, this booklinks relationships between its biological functions, structure andphysical'chemical properties. It will be an invaluableresource to researchers, both industrial and academic, involved inall aspects of hyaluronan-based technologies."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/2064860360> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isSimilarTo <http://worldcat.org/entity/work/data/2064860360#CreativeWork/hyaluronic_acid> ;
    schema:name "Hyaluronic acid : preparation, properties, application in biology and medicine"@en ;
    schema:productID "893202820" ;
    schema:url <http://0-ebookcentral.proquest.com.oasys.lib.oxy.edu/lib/oxy/detail.action?docID=1895546> ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=956995> ;
    schema:url <http://ebookcentral.proquest.com/lib/concordiaab-ebooks/detail.action?docID=1895546> ;
    schema:url <http://ebookcentral.proquest.com/lib/rdc/detail.action?docID=1895546> ;
    schema:url <http://dx.doi.org/10.1002/9781118695920> ;
    schema:url <http://onlinelibrary.wiley.com/book/10.1002/9781118695920> ;
    schema:url <http://site.ebrary.com/id/11022770> ;
    schema:url <http://catalogimages.wiley.com/images/db/jimages/9781118633793.jpg> ;
    schema:url <http://www.myilibrary.com?id=770008> ;
    schema:url <http://ebookcentral.proquest.com/lib/gprc-ebooks/detail.action?docID=1895546> ;
    schema:url <http://rbdigital.oneclickdigital.com> ;
    schema:url <http://ebookcentral.proquest.com/lib/macewan-ebooks/detail.action?docID=1895546> ;
    schema:workExample <http://worldcat.org/isbn/9781118695951> ;
    schema:workExample <http://worldcat.org/isbn/9781118695937> ;
    schema:workExample <http://worldcat.org/isbn/9781118633793> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/893202820> ;
    .


Related Entities

<http://0-ebookcentral.proquest.com.oasys.lib.oxy.edu/lib/oxy/detail.action?docID=1895546>
    rdfs:comment "Read e-book on Ebook Central (Occidental College authentication required)" ;
    .

<http://ebookcentral.proquest.com/lib/concordiaab-ebooks/detail.action?docID=1895546>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://ebookcentral.proquest.com/lib/gprc-ebooks/detail.action?docID=1895546>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://ebookcentral.proquest.com/lib/macewan-ebooks/detail.action?docID=1895546>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://ebookcentral.proquest.com/lib/rdc/detail.action?docID=1895546>
    rdfs:comment "from Ebook Central Academic Complete" ;
    rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://experiment.worldcat.org/entity/work/data/2064860360#Person/boykov_petr_ya> # Petr Ya Boykov
    a schema:Person ;
    schema:familyName "Boykov" ;
    schema:givenName "Petr Ya" ;
    schema:name "Petr Ya Boykov" ;
    .

<http://experiment.worldcat.org/entity/work/data/2064860360#Person/khabarov_vladimir_n> # Vladimir N. Khabarov
    a schema:Person ;
    schema:familyName "Khabarov" ;
    schema:givenName "Vladimir N." ;
    schema:name "Vladimir N. Khabarov" ;
    .

<http://experiment.worldcat.org/entity/work/data/2064860360#Person/selyanin_mikhail_a> # Mikhail A. Selyanin
    a schema:Person ;
    schema:familyName "Selyanin" ;
    schema:givenName "Mikhail A." ;
    schema:name "Mikhail A. Selyanin" ;
    .

<http://experiment.worldcat.org/entity/work/data/2064860360#Topic/medical_physiology> # MEDICAL--Physiology
    a schema:Intangible ;
    schema:name "MEDICAL--Physiology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2064860360#Topic/science_life_sciences_human_anatomy_&_physiology> # SCIENCE--Life Sciences--Human Anatomy & Physiology
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Human Anatomy & Physiology"@en ;
    .

<http://onlinelibrary.wiley.com/book/10.1002/9781118695920>
    rdfs:comment "URL des Erstveröffentlichers" ;
    .

<http://worldcat.org/entity/work/data/2064860360#CreativeWork/hyaluronic_acid>
    a schema:CreativeWork ;
    rdfs:label "Hyaluronic acid." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/893202820> ; # Hyaluronic acid : preparation, properties, application in biology and medicine
    .

<http://worldcat.org/isbn/9781118633793>
    a schema:ProductModel ;
    schema:isbn "1118633792" ;
    schema:isbn "9781118633793" ;
    .

<http://worldcat.org/isbn/9781118695937>
    a schema:ProductModel ;
    schema:isbn "1118695933" ;
    schema:isbn "9781118695937" ;
    .

<http://worldcat.org/isbn/9781118695951>
    a schema:ProductModel ;
    schema:isbn "111869595X" ;
    schema:isbn "9781118695951" ;
    .

<http://www.worldcat.org/title/-/oclc/893202820>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/893202820> ; # Hyaluronic acid : preparation, properties, application in biology and medicine
    schema:dateModified "2017-11-17" ;
    void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.