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Material Type: | Thesis/dissertation |
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Document Type: | Book |
All Authors / Contributors: |
Sébastien Bonnet; Jean-Pierre Savineau; Université de Bordeaux II (1970-2013). |
OCLC Number: | 491315795 |
Description: | 178 f. ; 30 cm. |
Responsibility: | Sébastien Bonnet ; sous la dir. de Jean Pierre Savineau. |
Abstract:
Pulmonary circulation response to hypoxia by a vasoconstriction. This response allows a good control of the ventilation perfusion ratio. Prolonged hypoxic exposure leads to pulmonary hypertension. It is now well recognised that the pulmonary artery smooth muscle cells (PASMCs) are a main actor of the hypoxic response. Hypoxia induces membrane depolarization which in turn increase the intracellular calcium concentration [Ca2+]i) in PASMCs and elevate vasomotor tone. PASMCs membrane potential (Em) is controlled by numerous potassium channels including Kv and Kca channels. However, no detailed studies have been performed on the electrophysiological and expression changes of BKca in CH rats PASMCs. Then we studied effects of CH on cytosolic calcium concentration ([Ca2+]i) and effect of CH on PASMCs calcium response to various agonist, such as (endotheline-1 (ET-1) ; angiotensin II (AII) ;ATP). Alterations of those responses are mainly due to the inhibition of the Ca-ATPase by CH.
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