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Hypoxia and cancer : biological implications and therapeutic opportunities

Author: Giovanni Melillo
Publisher: New York : Springer, 2014.
Series: Cancer drug discovery and development
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Giovanni Melillo
ISBN: 9781461491675 1461491673 1461491665 9781461491668
OCLC Number: 865580717
Notes: Includes index.
Description: 1 online resource (xiv, 363 pages) : illustrations (some color).
Contents: Part I. Biology --
Hypoxia and Breast Cancer Metastasis / Luana Schito and Gregg L. Semenza --
Hypoxia and the DNA Damage Response / Monica M. Olcina and Ester M. Hammond --
Emerging Roles of Non-Coding RNAs in the Hypoxic Response / Mircea Ivan, Xiaoling Zhong, Simona Greco and Fabio Martelli --
Hypoxia and Reactive Oxygen Species / Agnes Görlach --
Hypoxia and Gene Expression / Maria Carla Bosco and Luigi Varesio --
Carbonic Anhydrase IX: From Biology to Therapy / Silvia Pastorekova and Claudiu T. Supuran --
Part II. Imaging --
Imaging the Hypoxic Tumor Microenvironment in Preclinical Models / Mary-Keara Boss, Gregory M. Palmer and Mark W. Dewhirst --
Clinical Imaging of Hypoxia / Michael R. Horsman, DMSc, Morten Busk, Thomas Nielsen, Marianne Nordsmark and Jens Overgaard --
Part III. Therapy --
Hypoxia, Metastasis, and Antiangiogenic Therapies / Dietmar W. Siemann, Yao Dai and Michael R. Horsman --
The Unfolded Protein Response and Therapeutic Opportunities / Carly M. Sayers, Souvik Dey, Stacey L. Lehman and Constantinos Koumenis --
Small Molecules Targeting the VHL/Hypoxic Phenotype / Raymond J. Louie, Mercè Padró, Amato J. Giaccia and Denise A. Chan --
Hypoxia and Radiation Therapy / Marianne Nordsmark, Jan Alsner, Morten Busk, Jens Overgaard and Michael R. Horsman --
Prodrug Strategies for Targeting Tumour Hypoxia / William R. Wilson, Kevin O. Hicks, Jingli Wang and Frederik B. Pruijn --
Exploiting "Hif Addiction" For Cancer Therapy / Nicole D. Fer and Annamaria Rapisarda --
Clinical Exploitation of Hypoxia / Geoff S Higgins and Adrian L Harris.
Series Title: Cancer drug discovery and development
Responsibility: Giovanni Melillo, editor.

Abstract:

The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues.  Read more...

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