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I domain integrins

Author: Donald E Gullberg
Publisher: Dordrecht : Springer, [2014] ©2014
Series: Advances in experimental medicine and biology, v. 819.
Edition/Format:   Print book : English : Second editionView all editions and formats
Summary:
"The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I  Read more...
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Additional Physical Format: Online verison:
I domain integrins.
Dordrecht : Springer, 2014
(OCoLC)884961225
Document Type: Book
All Authors / Contributors: Donald E Gullberg
ISBN: 9789401791526 940179152X
OCLC Number: 879245665
Notes: Revised edition of: I domains in integrins / [edited by] Donald Gullberg. Landesbioscience/Eurekah.com, ©2003.
Description: xiv, 179 pages : illustrations (some color) ; 27 cm.
Contents: Evolution of integrin I domains / Mark S. Johnson and Bhanupratap Singh Chouhan --
Integrin [alpha]1[beta]1 / Humphrey Gardner --
[alpha]2[beta]1 integrin / Aasakiran Madamanchi, Samuel A. Santoro, and Mary M. Zutter --
Integrin [alpha]10[beta]1: a collagen receptor critical in skeletal development / Evy Lundgren-Åkerlund and Attila Aszòdi --
Integrin [alpha]11[beta]1: a major collagen receptor on fibroblastic cells / Cédric Zeltz, Ning Lu, and Donald Gullberg --
Regulation of integrin activity by phosphorylation / Carl G. Gahmberg, Mikaela Grönholm, and Liisa M. Uotila --
Integrin [alpha]E[beta]7: molecular features and functional significance in the immune system / Gregg A. Hadley and Jonathan M.G. Higgins --
Structural aspects of integrins / Robert C. Liddington --
Integrin recognition motifs in the human collagens / Samir Hamaia and Richard W. Farndale --
Cellular signaling by collagen-binding integrins / Jyrki Heino --
The therapeutic potential of I-domain integrins / Marian Brennan and Dermot Cox.
Series Title: Advances in experimental medicine and biology, v. 819.
Other Titles: I domain in integrins.
Responsibility: Donald Gullberg, editor.

Abstract:

The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits.  Read more...

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   schema:description ""The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.""@en ;
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