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Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS

Author: Swapan K Chowdhury
Publisher: Amsterdam : Elsevier, 2005.
Series: Progress in pharmaceutical and biomedical analysis, v. 6.
Edition/Format:   eBook : Document : English : 1st edView all editions and formats
Summary:
As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS.
Amsterdam : Elsevier, 2005
(OCoLC)62309605
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Swapan K Chowdhury
ISBN: 9780444517104 0444517103 0080456065 9780080456065
OCLC Number: 162130070
Description: 1 online resource (xvi, 338 pages) : illustrations.
Contents: Introduction: LC-MS and Drug Metabolism: A Journey Back in Time, Present Trends and Future Direction. --
Strategies for Increasing Throughput for PK Samples in a Drug Discovery Environment. --
Commonly Encountered Analytical Problems and their Solutions in Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) Methods Uded in Drug Development. --
Pitfalls in Quantitative LC-MS/MS: Metabolites Contributing to Measured Drug Concentrations. --
In <IT>vitro</IT> DMPK Sreening in Drug Discovery, Role of LC-MS/MS. --
Metabolite Identification by LC-MS: Applications in Drug Discovery and Development. --
Screening for the Assessment of Electrophilic Metabolite Formation Early in Drug Discovery Using HPLC-MS. --
Liquid chromatography Tandem Mass Spectrometry-Based Metabolite Identification Strategies in Pharmaceutical Research. --
Quantification and Structural Elucidation of Low Quantities of Radiolabeled Metabolites Using Microplate Scintillation Counting (MSC) Techniques in Conjunction with LC-MS. --
--
Oxidative Metabolites of Drugs and Xenobiotics: LC-MS Methods to Identify and Characterize in Biological Matrices. --
Detection and Charactrization of Highly Polar Metabolites by LC-MS: Proper Selection of LC Column and Use of Stable Isotope Labeled Drug to Study Metabolism of Rabavirin in Rats. --
Cytochrome P450 (CYP) and UDP-Glucuronosyltransferase (UGT) Enzymes: Role in Drug Metabolism, Polymorphism, and Identification of their Involvement in Drug Metabolism.
Series Title: Progress in pharmaceutical and biomedical analysis, v. 6.
Responsibility: edited by Swapan K. Chowdhury.

Abstract:

Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a range of drug metabolism studies. This book provides a comprehensive description of  Read more...

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