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Idiopathic complex polysaccharide storage disease in an abyssinian cat.
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Idiopathic complex polysaccharide storage disease in an abyssinian cat.

Author: IM Langohr Affiliation: Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2065, USA. ilangohr@purdue.edu; M Tanabe
Edition/Format: Article Article : English
Publication:Veterinary pathology, 2005 Jul; 42(4): 502-6
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Other Databases: ArticleFirst
Summary:
A glycogen storage disease affecting primarily the skeletal muscle and, to a lesser degree, the cardiac muscle, spinal cord, and brain was diagnosed in a 10-year-old neutered Abyssinian cat with a 4-year history of paresis progressing to acute paralysis. Microscopically, these tissues contained inclusions that were pale basophilic in hematoxylin and eosin-stained slides, diastase resistant, periodic acid-Schiff  Read more...
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Document Type: Article
All Authors / Contributors: IM Langohr Affiliation: Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2065, USA. ilangohr@purdue.edu; M Tanabe
ISSN:0300-9858
Language Note: English
Unique Identifier: 110803230
Awards:

Abstract:

A glycogen storage disease affecting primarily the skeletal muscle and, to a lesser degree, the cardiac muscle, spinal cord, and brain was diagnosed in a 10-year-old neutered Abyssinian cat with a 4-year history of paresis progressing to acute paralysis. Microscopically, these tissues contained inclusions that were pale basophilic in hematoxylin and eosin-stained slides, diastase resistant, periodic acid-Schiff positive, and blue-to-almost black with iodine stain. By transmission electron microscopy, the inclusions consisted of cytosolic, usually sharply demarcated, nonmembrane-bound deposits of finely granular and filamentous material. On the basis of the structural and histochemical staining characteristics, the inclusions were believed to be aggregates of abnormally stored, unbranched glycogen. A defect in glucose metabolism is suspected to be the underlying pathologic process, but an exact cause remains elusive.

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