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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/111808320 Title: Immunosuppression in the northern leopard frog (Rana pipiens) induced by pesticide exposure. Publisher: ISBN/ISSN: 0730-7268 OCLC:111808320

  
  

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Immunosuppression in the northern leopard frog (Rana pipiens) induced by pesticide exposure.

Author:	MK Gilbertson; GD Haffner; KG Drouillard; A Albert; B Dixon
Edition/Format:	Article : English
Publication:	Environmental toxicology and chemistry / SETAC, 2003 Jan; 22(1): 101-10
Database:	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Other Databases:	British Library Serials; ArticleFirst
Summary:	An injection study and a field study were used to investigate the hypothesis that environmental xenobiotics have the potential to alter the immune function of northern leopard frogs (Rana pipiens). Three assays, IgM-specific antibody response to keyhole limpet hemocyanin linked to dinitrophenyl (KLH-DNP), zymozan induced chemiluminescence (CL) of whole blood and the delayed-type hypersensitivity (DTH), were used to assay humoral, innate and cell-mediated immune endpoints. Sublethal doses of DDT (923 ng/g wet wt), malathion (990 ng/g wet wt), and dieldrin (50 ng/g wet wt) were used in the injection study. In all pesticide-injected groups, antibody response was dramatically suppressed, DTH reactions were enhanced, and respiratory burst was lower. When the order of administration of pesticides and antigens was reversed, no differences in immune function between the control and dosed groups were apparent, indicating that frogs exposed to pathogens prior to pesticide exposure can still respond. A field study found significant differences in immune function between frog populations in pesticide-exposed and pesticide-free locations. The antibody response and CL were suppressed and the DTH enhanced in frogs from Essex County (ON, Canada). Overall, the results suggest that exposure to these pesticides can cause both stimulatory and suppressive immune changes in adult frogs and is doing so in wild populations.  Read more...
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