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Impedimetric biosensors for medical applications : current progress and challenges

Author: Jo V RushworthNatalie A HirstJack A GoodeDouglas J PikeAsif AhmedAll authors
Publisher: New York, NY : ASME Press : Momentum Press, [2013]
Series: Biomedical & nanomedical technologies.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of  Read more...
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Details

Document Type: Book
All Authors / Contributors: Jo V Rushworth; Natalie A Hirst; Jack A Goode; Douglas J Pike; Asif Ahmed; Paul Millner
ISBN: 9780791860243 0791860248
OCLC Number: 864090477
Description: 70 pages : illustrations ; 24 cm.
Contents: 1. Introduction and scope --
2. Biosensors --
2.1 Brief history of biosensor development --
2.2 Applications of biosensors --
2.3 Biosensor architecture, an overview --
2.4 Biorecognition element --
2.5 Transducer element --
2.6 Summary --
3. Electrochemical impedance spectroscopy --
3.1 Brief history of the development of impedimetric biosensors --
3.2 An overview of impedance --
3.3 Principles of impedimetric sensing --
3.4 Presenting and analysing impedance data --
4. Fabrication of impedimetric biosensors --
4.1 Electrode design and materials --
4.2 Bioreceptor tethering to transducer surfaces --
5. Commercializing impedimetric biosensors: from laboratory to field --
5.1 Components of a point-of-care diagnostic device --
5.2 From research to point-of-care --
5.3 Sample delivery & processing --
5.4 Sensor regeneration --
5.5 Barriers to commercialisation --
6. Case studies of impedimetric biosensors for medical applications --
6.1 Whole cells and pathogenic microorganisms --
6.2 Protein and peptide biomarkers of disease --
6.3 Small molecules --
7. Conclusions and future perspectives --
8. Author biographies --
References.
Series Title: Biomedical & nanomedical technologies.
Responsibility: Jo V. Rushworth, Natalie A. Hirst, Jack A. Goode, Douglas J. Pike, Asif Ahmed, Paul A. Millner.

Abstract:

In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer- by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalisation and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph describes case studies of successful impedance-based biosensors for the detection of a range of analytes from small molecules up to whole microorganisms. Finally, the authors put forward future perspectives for the clinical applications of impedimetric biosensors. --

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