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Implementing precision medicine in best practices of chronic airway diseases

Author: Ioana Agache; Peter W Hellings
Publisher: London, United Kingdom : Academic Press, an imprint of Elsevier, [2019].
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Agache, Ioana
Implementing Precision Medicine in Best Practices of Chronic Airway Diseases
San Diego : Elsevier Science & Technology,c2018
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ioana Agache; Peter W Hellings
ISBN: 9780128134726 0128134720
OCLC Number: 1054255128
Description: 1 online resource : illustrations, map
Contents: Front Cover; Implementing Precision Medicine in Best Practices of Chronic Airway Diseases; Copyright Page; Contents; List of Contributors; Foreword; I. The Concept of Precision Medicine and Precision Health; 1 The Audacious Goal of Precision Medicine; Further Reading; 2 Critical Entry Points-Genetics and Epigenetics; Critical Entry Points-Genetics and Epigenetics; Genetics: An Overview; Genetics of CRS; Epigenetics in CRS; Clinical Uses of Genetics and Genotyping in CRS; Characterization of Unexplained Immune Deficiencies; Assessment and Selection of Therapy for Cystic Fibrosis Predictive GeneticsTaste Receptors; Staphyloccus aureus Carriage in CRSwNP; Summary and Future Perspectives; 3 Critical Entry Points-Microbiome; Introduction; Microbiome Evolution in Early Life; Microbiome-Host Mechanisms; Microbiome in Asthma Patients; Microbiome in Allergic Rhinitis and Chronic Rhinosinusitis; Microbiome in Precision Medicine; Conclusions; References; 4 Factors Modulating the Disease Endotype; The complex immune-inflammatory network driving the endotype; The relation with the remodeled phenotype; The epigenetic influences; The role of the exposome Metabolic and endocrine pathwaysNeuroimmune factors; Conclusion; References; 5 Revised Disease Nomenclature Including Disease Endotypes; Introduction; Endotypes of Allergic Diseases; New Approach to Nomenclature; Asthma Endotypes; References; II. Shortcomings of Current Care Pathways for Chronic Airways Diseases; 6 The Global Burden of Chronic Airway Diseases; Introduction; References; 7 Unmet Needs in Chronic Upper Respiratory Tract Diseases; General Principles; Defining Patient Subpopulations; Etiology and Pathophysiology; Guidelines and Consensus Documents; Treatment; Conclusion Key PointsReferences; III. Personalized care: endotype-driven treatment; 8 Endotype-Driven Approach for Asthma; Asthma Phenotypes and Endotypes; Type-2 Asthma Endotype; Non-Type-2 Asthma Endotype; Conclusions; References; 9 Endotype-Driven Approach for Chronic Rhinosinusitis; Abbreviations; Introduction; Endotypes Based on T-Helper Cells; Endotyping of CRS; Treatment Approaches to Endotypes; Conclusion; Source of Funding; References; 10 Endotype-Driven Approach in Rhinitis; References; 11 Prevention of Allergies; Abbreviations; Introduction and Epidemiology; Primary Prevention Secondary PreventionTertiary Prevention; Risk Factors and Protective Factors; Genetic and Epigenetic Aspects; Family History and Allergy Susceptibility Genes; Epigenetic Regulation in Allergic Disease; Environmental Aspects; Siblings and Day Nursery; Farm Effect; Nutrition and Breastfeeding; Cesarean Section; Indoor Air; Pets; Outdoor Air Pollution; Climate Change; Occupational Allergies; Consequences for Allergy Prevention; Do's and Don'ts of Allergy Prevention; Research Needs and Outlook; Individualized Prevention; References; 12 Prevention of Asthma
Responsibility: edited by Ioana Agache, Peter Hellings.

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