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Indacaterol : the first once-daily long-acting Beta2 Agonist for COPD

Author: Alexandre Trifilieff
Publisher: Basel : Springer, 2014.
Series: Milestones in drug therapy
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Alexandre Trifilieff
ISBN: 9783034807098 3034807090 3034807082 9783034807081
OCLC Number: 867547877
Description: 1 online resource (vii, 146 pages) : illustrations (some color).
Contents: Current Pharmacotherapy for COPD / James F. Donohue, Matthew C. Miles and Jill A. Ohar --
The Preclinical Pharmacology of Indacaterol / Alexandre Trifilieff, Steven J. Charlton and Robin A. Fairhurst --
The Design of the Indacaterol Molecule / Robin A. Fairhurst, Steven J. Charlton and Alexandre Trifilieff --
The Early Clinical Development of Indacaterol / Jutta Beier and Kai M. Beeh --
INHANCE: An Adaptive Confirmatory Study with Dose Selection at Interim / David Lawrence, Frank Bretz and Stuart Pocock --
Phase 3 Clinical Efficacy Studies: Lung Function / Ronald Dahl --
Phase III Clinical Efficacy of Indacaterol: Patient-Centered Outcomes / Donald A. Mahler --
The History and Performance of the Breezhaler Device / David Young, Lee Wood, Dilraj Singh and Juergen Dederichs --
What Does the Future Hold for the Therapy of COPD? / Peter J. Barnes. Current Pharmacotherapy for COPD --
The preclinical pharmacology of indacaterol --
The design of the indacaterol molecule --
The early clinical development of Indacaterol --
INHANCE: An adaptive confirmatory study with dose selection at interim --
Phase III clinical efficacy studies: lung function --
Phase III Clinical Efficacy of Indacaterol --
Patient-centered Outcomes --
The history and performance of the Breezhaler device --
What does the future hold for the therapy of COPD?
Series Title: Milestones in drug therapy
Responsibility: Alexandre Trifilieff, editor.

Abstract:

Here is a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled ss2 agonist for treating COPD. Covers design and pre-clinical pharmacology of the  Read more...

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