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Individual susceptibility to genotoxic agents in the human population

Author: Frederick J De Serres; Ronald W Pero; William Sheridan; National Institute of Environmental Health Sciences.
Publisher: New York : Plenum Press, ©1984.
Series: Environmental science research, v. 30.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats

Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B.


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Genre/Form: Congresses
Conference papers and proceedings
Additional Physical Format: Online version:
Individual susceptibility to genotoxic agents in the human population.
New York : Plenum Press, ©1984
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Frederick J De Serres; Ronald W Pero; William Sheridan; National Institute of Environmental Health Sciences.
ISBN: 0306416794 9780306416798
OCLC Number: 10778537
Notes: "Proceedings of a workshop on individual susceptibility genotoxic agents in the human population, held May 10-12, 1982, at the National Institute of Environmental Health Sciences, in Research Triangle Park, North Carolina."
Description: x, 518 pages : illustrations ; 26 cm.
Contents: Session I: Genotoxic Substances and Variability in Human Disease.- Investigation of Genetic Hazards: Guidance from Occupational and Environmental Studies.- Epidemiology and Population Monitoring in Genetic Risk Assessment.- An Overview of Approaches for Genetic Monitoring of Humans.- Evaluation of Genotoxic Effects in Human Populations.- Session II: Metabolism of Genotoxic Agents in Human Cells and its Relevance to Risk Assesment.- On the Possible Significance of TCDD Receptor Based Assays in Attempts to Estimate Environmental Health Hazards.- Interindividual Differences in Monooxygenase Activities of Human Liver.- Involvement of Prostaglandin Synthetase in the Metabolic Activation of Chemical Carcinogens - Phenacetin as an Example.- The Use of Immunological and Molecular Biological Techniques in the Assessment of Occupational and Environmental Disease.- Interindividual Variation in the DNA Binding of Chemical Genotoxins Following Metabolism by Human Bladder and Bronchus Explants.- Session III: Genotoxic Testing on Somatic Cells in the Human Population.- Intrinsic Factors that Can Affect Sensitivity to Chromosome Aberration Induction.- Individual Variability in the Frequency of Sister Chromatid Exchange in Human Lymphocytes.- Variations in Mitotic Index and Chromosomal Aberration Rates in Women.- Micronuclei in Cultured Lymphocytes as an Indicator of Genotoxic Exposure.- Detection of Mutated Erythrocytes in Man.- Peripheral Blood Lymphocytes as Indicator Cells for in vivo Mutation in Man.- Discrimination between Spontaneous and Induced Mutations in Human Cell Populations by Use of Mutational Spectra.- Session IV: Evaluation of Body Tissues and Fluids as Indicators of Exposure.- Short Term Tests on Body Fluids.- Chemical Analysis of Human Samples: Identification and Quantification of Polychlorinated Dioxins and Dibenzofurans.- Hemoglobin as a Dose Monitor of Alkylating Agents: Determination of Alkylation Products of N-Terminal Valine.- Session V: Population Heterogeneity as a Modifier of Genotoxic response.- Variations in Sensitivity and DNA Repair in Human Cells Exposed to Genotoxic Agents.- Unscheduled DNA Synthesis Induced by N-Acetoxy-2-acetylaminofluorene as an Indicator of Risk from Genotoxic Exposures.- Individual Variation in DNA Repair in Human Peripheral Blood Monocytes.- Influence of Demographic Factors on Unscheduled DNA Synthesis as Measured in Human Peripheral Leukocytes and Fibroblasts.- Individual Variation in Benzo(a)pyrene Metabolism and Its Role in Human Cancer.- C-Band Variation in Hypertensive Men.- Session VI: Reproductive Effects of Genotoxic Exposures on the Human Population.- Methods for Evaluating the Effects of Environmental Chemicals on Human Spermatogenesis.- New Techniques for Detecting Chromosome Abnormalities in the Germ-Line in Man.- Epidemiologic Considerations in Assessing Adverse Reproductive Outcomes Following Genotoxic Exposures.- Session VII: Genotoxic Risk Monitoring of the General Population.- A Reference Population: For the Evaluation of Natural Occurring Inter-individual Variation in the Response to Genotoxic Agents.- Investigations of Smoking and Related Health Complications and Genotoxic Hazards in a Preventive Medical Population Program in Malmoe, Sweden.
Series Title: Environmental science research, v. 30.
Responsibility: edited by Frederick J. de Serres and Ronald W. Pero ; technical editor, William Sheridan.


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