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Inflammation and retinal disease : complement biology and pathology

Author: J D Lambris; Anthony P Adamis
Publisher: New York : Springer, ©2010.
Series: Advances in experimental medicine and biology, v. 703.
Edition/Format:   eBook : Document : Conference publication : EnglishView all editions and formats
Summary:
Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic  Read more...
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Genre/Form: Electronic books
Conference papers and proceedings
Congresses
Additional Physical Format: Print version:
Inflammation and retinal disease
Material Type: Conference publication, Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: J D Lambris; Anthony P Adamis
ISBN: 9781441956354 1441956352
OCLC Number: 668097991
Description: 1 online resource (xiii, 167 pages) : illustrations.
Contents: The case for complement and inflammation in AMD : open questions / Natalia Karagianni and Anthony P. Adamis --
The role of complement in AMD / Peter F. Zipfel, Nadine Lauer, and Christine Skerka --
Multiple interactions of complement factor H with its ligands in solution : a progress report / Stephen J. Perkins [and others] --
Genetic control of complement activation in humans and age related macular degeneration / Laura A. Hecker and Albert O. Edwards --
Bisretinoids of RPE lipofuscin : trigger for complement activation in age-related macular degeneration / Janet R. Sparrow --
The role of the classical complement cascade in synapse loss during development and glaucoma / Allison M. Rosen and Beth Stevens --
A role for complement in glaucoma? / Lizhen Ren and John Danias --
The ATP-binding cassette transporter ABCA4 : structural and functional properties and role in retinal disease / Yaroslav Tsybovsky, Robert S. Molday, and Krzysztof Palczewski --
Suppression of drusen formatino by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degereration / Zai-Long Chi [and others] --
A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration / Bärbel Rohrer [and others] --
Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration / David C. Fritzinger [and others].
Series Title: Advances in experimental medicine and biology, v. 703.
Responsibility: John D. Lambris, Anthony P. Adamis, editors.

Abstract:

Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). This volume represents a collection of topics  Read more...

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