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Inhibition of Folate Metabolism in Chemotherapy : the Origins and Uses of Co-trimoxazole

Author: George H Hitchings
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1983.
Series: Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie,, 64.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
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With contributions by numerous experts

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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: George H Hitchings
ISBN: 9783642818905 3642818900 9783642818929 3642818927
OCLC Number: 840301070
Description: 1 online resource.
Contents: Trimethoprim/Sulfamethoxazole: An Overview --
A. Introduction --
B. Mechanisms of Action --
C. Resistance --
D. Clinical Use of TMP/SMX --
E. Use of TMP or SMX as Single Agents --
F. Adverse Effects --
G. Summary --
References --
Pharmacology and Biochemistry --
1 Functions of Tetrahydrofolate and the Role of Dihydrofolate Reductase in Cellular Metabolism --
2 Sulfonamides: Structure-Activity Relationships and Mechanism of Action --
3 Dihydrofolate Reductase --
4 Antibacterial Activity --
5 Selective Inhibitors of Bacterial Dihydrofolate Reductase: Structure-Activity Relationships --
6 Kinetics of Antibacterial Effects --
7 Disposition and Metabolism of Trimethoprim, Tetroxoprim, Sulfamethoxazole, and Sulfadiazine --
8 Preclinical Toxicity Testing of Co-trimoxazole and Other Trimethoprim/ Sulfonamide Combinations --
Clinical Pharmacology --
9 Adverse Effect of Co-trimoxazole --
10 Clinical Pharmacokinetics of Co-trimoxazole --
11 Resistance: Genetics and Medical Implications --
Clinical Studies --
12 Trimethoprim Alone: Clinical Uses --
13 Inhibitors of Dihydrofolate Reductase as Antiprotozoal Agents --
14 Pediatric Uses of Sulfonamides, Trimethoprim, and the Combination --
15 Use of Co-trimoxazole in Urinary Tract Infection --
16 Treatment of Genital Infections with Trimethoprim, Sulfonamides, and Combinations --
17 Treatment of Enteric Infections and Combinations --
18 Prostatitis --
19 Co-trimoxazole in Chest Infections Including its Long-Term Use in Chest Disease --
20 Treatment of Miscellaneous and Unusual Infections with Trimethoprim and Trimethoprim/Sulfonamide Combinations.
Series Title: Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie,, 64.
Other Titles: With contributions by numerous experts
Responsibility: edited by George H. Hitchings.
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