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Innate immune sensing and response

Author: Bruce Beutler
Publisher: London : Henry Stewart Talks, 2009.
Series: Henry Stewart talks., Biomedical & life sciences collection., Innate immunity : host recognition and response in health and disease.
Edition/Format:   eVideo : Clipart/images/graphics : EnglishView all editions and formats
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Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: Bruce Beutler
OCLC Number: 431950465
Notes: Animated audio-visual presentation with synchronized narration.
Title from title frames.
Description: 1 streaming video file (62 min.).
Contents: Sensing infection is essential to the initiation of an immune response --
The innate immune system senses signature molecules made by microbes using a conserved set of germline-encoded receptors --
This receptor family (the Toll-like receptors) was first understood when a mutation that abolished lipopolysaccharide (LPS) sensing was positionally cloned in mice --
In Drosophila a homologous receptor is also used to detect infection, and still another receptor activates a pathway evocative of the tumor necrosis factor (TNF) pathway in mammals --
Further work in mammals has depended upon gene targeting and also forward genetic work, which has revealed many of the components of the TLR signaling apparatus --
Forward genetics has also allowed us to see how many genes (and what kinds of genes) are important for resisting an infection in vivo.
Series Title: Henry Stewart talks., Biomedical & life sciences collection., Innate immunity : host recognition and response in health and disease.
Responsibility: Bruce Beutler.
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