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Interleukin 12 : antitumor activity and immunotherapeutic potential in oncology

Author: Witold Lasek; Radoslaw Zagozdzon; Marek Jakóbisiak
Publisher: Cham, Switzerland : Springer, ©2016.
Series: SpringerBriefs in immunology.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Lasek, Witold.
Interleukin 12.
Cham, Switzerland : Springer, ©2016
(OCoLC)957509038
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Witold Lasek; Radoslaw Zagozdzon; Marek Jakóbisiak
ISBN: 9783319469065 3319469061
OCLC Number: 959952988
Description: 1 online resource.
Contents: *Biology of IL-12 -1.1.Molecular structure of IL-12,-1.2.IL-12 receptor, -1.3.Regulation of IL-12 expression,- 1.4.Role of IL-12 in antitumor immunity,- 1.5.References 2*Antitumor effects of IL-12 in preclinical studies -2.1.IL-12 in a single-agent therapy and in the combined treatment of animal tumors,-2.2.Experimental IL-12-based gene therapy,-2.3.References 3*Clinical trials with IL-12 in cancer immunotherapy -3.1.Early clinical studies,-3.2.Cutaneous T cell lymphoma (CTCL),-3.3.Hodgkin's and non-Hodgkin's lymphoma,-3.4.Kaposi's sarcoma,-3.5.Trends in IL-12-based approaches in oncology,-3.6.References.
Series Title: SpringerBriefs in immunology.
Responsibility: Witold Lasek, Radoslaw Zagozdzon ; with a contribution by Marek Jakóbisiak.
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Abstract:

This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

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