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Intractable epilepsies

Author: Warren T Blume; Peter L Carlen
Publisher: Philadelphia : Lippincott Williams & Wilkins, ©2006.
Series: Advances in neurology, v. 97.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"Based on proceedings of the 2004 Canadian League Against Epilepsy Conference, this volume brings together the latest developments in the understanding, diagnosis, and management of intractable epilepsies. Inside you'll examine the views of noted experts, as they review cutting-edge medications, explore strategies for designing new drugs, and offer patient-management guidelines for both adults and children."--BOOK  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Warren T Blume; Peter L Carlen
ISBN: 9780781758154 0781758157
OCLC Number: 62867487
Description: xxvii, 595 pages : illustrations, portrait.
Contents: Burden of intractable epilepsy --
Defining intractable epilepsy --
Outcome measures in intractable epilepsy --
Focal seizures: intractability and semiology --
Syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis --
Clinical aspects of temporal/limbic epilepsy and their relationships to intractability --
Clinical electrophysiology factors indicative of intractability in patients with temporal lobe epilepsy --
Epilepsy-based changes in hippocampal excitability: causes and effects --
Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsy --
Parahippocampal networks, intractability, and the chronic epilepsy of kindling --
Novel mechanisms underlying drug resistance in temporal lobe epilepsy --
Failure of surgery for temporal lobe epilepsy: a review of selected aspects --
Neocortical epilepsy: aspects distinguishing intractable from benign neocortical epilepsies. Intractable epilepsies of the neocortex: basic mechanisms --
Simultaneous electroencephalogram-functional magnetic resonance imaging in neocortical epilepsies --
What intractability information is there in the type of generalized seizure? --
Neuronal substrates of spike-wave seizures and hypsarrhythmia in corticothalamic systems --
Novel strategies for the development of animal models of refractory epilepsy --
Participation of cortical glial cells to the genesis of spike-wave seizures --
Status epilepticus and refractory status epilepticus: introductory and summary statements --
Basic mechanisms in status epilepticus: role of calcium in neuronal injury and the induction of epileptogenesis --
Epidemiology and clinical presentation of status epilepticus --
Status epilepticus and brain damage: pathology and pathophysiology --
Nonconvulsive seizures and electroencephalogram monitoring in the intensive care unit --
Status epilepticus in pediatric practice: neonate to adolescent --
Current approach to the diagnosis and treatment of refractory status epilepticus --
Magnetic resonance imaging sequences for detection of lesions in refractory epilepsy --
Magnetic resonance imaging in intractable epilepsy: focus on structural image analysis. High-resolution magnetic resonance imaging (MRI), surface coil MRI, and magnetoencephalography --
Magnetic resonance spectroscopic techniques for localizing epileptogenic zones in refractory partial epilepsy --
Animal models of epilepsy and progressive effects of seizures --
Mechanisms that might underlie progression of the epilepsies and how to potentially alter them --
Clinical evidence that epilepsy is not a progressive disorder with special emphasis on epilepsy syndromes that do not progress --
Clinical evidence that epilepsy is a progressive disorder with special emphasis on epilepsy syndromes that do progress --
Psychosocial comorbidity in epilepsy --
Behavioral comorbidities: attention deficit hyperactivity disorder --
human and animal studies --
Medical comorbidity in intractable epilepsy --
Intractable epilepsy, hormonal and reproductive problems: human and animal studies --
Neuropsychological profiles --
Intractable epilepsy and patterns of psychiatric comorbidity --
Psychological treatment in intractable epilepsy: approaches, evidence, and future directions --
Monogenic epilepsies in humans: molecular mechanisms and relevance for the study of intractable epilepsy --
Polygenic epilepsy --
On the road to tractability: the current biochemical understanding of progressive myoclonus epilepsies. Major targets and mechanisms of antiepileptic drugs and major reasons for failure --
Designing future drugs for the treatment of intractable epilepsy --
Definition and prediction of intractable epilepsy in children --
Diseases and syndromes associated with intractable epilepsy --
Management of intractable epilepsy in infancy and childhood --
Spectrum of intractable epilepsy: a proposed scale --
Differential diagnostic considerations in patients with intractable epilepsy --
Investigations: how the data affect management --
Medical management of intractable epilepsy --
Assessment of patients with intractable epilepsy for surgery --
Palliative surgery for intractable epilepsy --
Evaluating surgery effectiveness --
Deep brain stimulation and cortical stimulation in the treatment of epilepsy.
Series Title: Advances in neurology, v. 97.
Responsibility: editor Warren T. Blume ; associate editors, Peter L. Carlen [and others].
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Abstract:

Aims to bring together the advances in understanding, diagnosis, and management of intractable epilepsies. This book reviews research and its clinical implications, explores strategies for designing  Read more...

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