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Intrinsic immunity

Author: Bryan Cullen
Publisher: Berlin ; New York : Springer, ©2013.
Series: Current topics in microbiology and immunology, v.371.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin  Read more...
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Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Bryan Cullen
ISBN: 9783642377655 3642377653
OCLC Number: 845039058
Notes: Includes index.
Description: 1 online resource.
Contents: The APOBEC3 Family of Retroelement Restriction Factors / Eric W. Refsland, Reuben S. Harris --
Inhibition of Retroviral Replication by Members of the TRIM Protein Family / Adam J. Fletcher, Greg J. Towers --
The Antiviral Activities of Tetherin / Stuart J. D. Neil --
Restriction of Retroviral Infection of Macrophages / Mark Sharkey --
Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors / Welkin E. Johnson --
RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants / György Szittya, József Burgyán --
RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates / Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino --
Roles of MicroRNAs in the Life Cycles of Mammalian Viruses / Eva Gottwein --
Interplay Between DNA Tumor Viruses and the Host DNA Damage Response / Karyn McFadden, Micah A. Luftig.
Series Title: Current topics in microbiology and immunology, v.371.
Responsibility: Bryan R. Cullen, editor.
More information:

Abstract:

Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.

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