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|Additional Physical Format:||Print version:
Cullen, Bryan R.
Dordrecht : Springer, ©2013
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Bryan R Cullen
|Notes:||7 Concluding Remarks.|
|Description:||1 online resource (264 pages).|
|Contents:||Preface; Contents; The APOBEC3 Family of Retroelement Restriction Factors; Abstract; 1 DNA Deaminase Evolution; 2 Biochemical and Structural Insights; 3 Biological Functions; 3.1 APOBEC3 Proteins in HIV Restriction; 3.2 APOBEC3 Proteins in General Innate Immune Defense; 4 Pathological Consequences of DNA Deamination; 5 Possible Avenues to APOBEC3-Based Therapeutics; 5.1 Therapy by Hypermutation; 5.2 Therapy by Hypomutation; References; Inhibition of Retroviral Replication by Members of the TRIM Protein Family; Abstract; 1 Introduction. 2 TRIM5[alpha] and TRIMCyp Bind Retroviral Capsids to Accelerate Their Degradation and Stimulate Innate Signaling2.1 Combining Two Activities; 2.2 The C-Terminal PRYSPRY has Surface Variable Loops that Determine Restriction Specificity; 2.3 TRIM5[alpha] Recognizes Multiple Capsid Epitopes to Maintain Broad Specificity; 2.4 TRIMCyp is Also a Versatile Capsid Recognition Domain; 2.5 TRIM5[alpha] Causes Structural Damage to Capsids; 2.6 TRIM5[alpha] Ubiquitination; 2.6.1 The Role of the RING; 2.6.2 TRIM5 Signaling; 2.7 TRIM5[alpha] Cytoplasmic Bodies as Components of Restriction. 3 TRIM28 is a Transcriptional Corepressor of Endogenous and Exogenous Retroviruses3.1 TRIM28 is a Molecular Scaffold for Heterochromatin-Inducing Enzymes; 3.2 TRIM28 Mediates Repression of Endogenous Retroviruses in Embryonic Stem Cells; 3.3 TRIM28 is Responsible for the Stem Cell-Specific Restriction of Murine Leukemia Viruses; 3.4 TRIM28-Mediated Restriction of Complex Retroviruses; 3.5 TRIM28 Restricts HIV-1 Integration by Facilitating Integrase Deacetylation; 3.6 TRIM28-Related Protein TRIM24 Represses ERV Transcription in Hepatocytes. 4 TRIM22 Represses HIV-1 LTR Transcription and is a Correlate of Viral Control in HIV-1-Infected Patients5 Do Other TRIM Family Proteins Inhibit Retroviral Replication?; 6 Concluding Remarks; References; The Antiviral Activities of Tetherin; Abstract; 1 Introduction; 2 Tetherin; 2.1 Structure and Subcellular Localization; 2.2 Mechanism of Tetherin's Antiviral Activity; 2.3 Genetic Diversity in Mammalian Tetherins; 2.4 Tissue expression and Transcriptional Regulation of Tetherin; 3 Viral Countermeasures of Tetherin; 3.1 Overview; 3.2 HIV-1 and SIV Vpu; 3.2.1 TetherinVpu Interactions. 3.2.2 Vpu-Mediated Subversion of Tetherin Trafficking3.2.3 Ubiquitination of Tetherin Induced by Vpu; 3.2.4 Degradation of Tetherin in Response to Vpu; 3.2.5 Impaired or Absent Tetherin Counteraction in SIVcpz and HIV-1 Non-group M Vpu Proteins: A Determinant of Pandemic Spread?; 3.3 SIV Nef; 3.4 HIV-2 and Other Lentiviral Envelope Proteins; 3.5 HHV8 K5; 3.6 Ebola Virus GP; 3.7 Other Viruses and Tetherin; 4 Tetherin and Cell-to-Cell Transmission of Retroviruses; 5 Tetherin and Viral Pathogenesis In vivo; 6 Tetherin as a Viral Sensor and Regulator of Antiviral Immune Responses.|
|Series Title:||Current topics in microbiology and immunology.|