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Introduction to cancer biology

Author: Robin Hesketh
Publisher: Cambridge : Cambridge University Press, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Hesketh, Robin.
Introduction to cancer biology.
Cambridge : Cambridge University Press, 2013
(DLC) 2012015670
(OCoLC)786245435
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Robin Hesketh
ISBN: 9781139840064 1139840061 9781139012904 1139012908 9781139842440 1139842447
OCLC Number: 822027272
Description: 1 online resource
Contents: Acknowledgements; Foreword; Introduction; 1 Lessons from epidemiology; Incidence; Deaths; Patterns around the world: how many cancers and what sort?; UK and USA; Europe; The rest of the world; Latin America; China; India; Africa; Trends; Age; Where do we stand and is there any good news?; Conclusions; Key points; Future directions; Further reading: reviews; Patterns around the world: how many cancers and what sort?; UK and USA; Europe; China; India; Africa; Trends; Cancer statistics websites; Global; UK and USA; Europe; Latin America; 2 Causes of cancer; Introduction; Infection. RadiationIonising radiation; Radon; Ultraviolet radiation; Low-frequency magnetic fields; High-frequency magnetic fields (mobile phones); Tobacco; Alcohol; Tea and coffee; Diet: epidemiological studies; Folate; Calcium; Fibre; Obesity; Stress; Conclusions; Key points; Future directions; Further reading: reviews; Infection; Ionising radiation; Ultraviolet radiation; Low-frequency magnetic fields (power lines and domestic electrical circuits); High-frequency magnetic fields (mobile phones); Diet: epidemiological studies; Obesity; Stress; 3 Signalling in normal cells; Introduction. Enzyme-coupled receptorsReceptor tyrosine kinases (RTKs); Intracellular signalling from activated tyrosine kinase receptors; Activating RAS and MAPK; Sustained versus transient activation of RAS and MAPK; Mitogenic activation of cell cycle progression; MYC is a central regulator of cell growth and proliferation; MYC and proliferation; Cytokine receptors; G-protein-coupled receptors; Ligand-gated ion channel receptors; Steroid hormones; Conclusions; Key points; Future directions; Further reading: reviews; Receptor tyrosine kinases (RTKs); Activating RAS and MAPK. Sustained versus transient activation of RAS and MAPKMYC is a central regulator of cell growth and proliferation; Cytokine receptors; G-protein-coupled receptors; Ligand-gated ion channel receptors; Steroid hormones; 4 'Cancer genes': mutations and cancer development; Collecting mutations; Genetic roulette; The cancer genomic landscape; Mutations in 'cancer genes': oncogenes and tumour suppressor genes; Oncogenes; The first human oncogene; What turns a proto-oncogene into an oncogene?; A single base change: RAS; Other coding mutations: the epidermal growth factor receptor (EGFR). Gene amplification: MYCChimeric protein: BCR-ABL1, PML-RARA and ETV6-RUNX1; Normal protein, abnormal control: MYC; Complete loss of a gene; Tumour suppressor genes; What does the retinoblastoma protein do?; Tumour protein 53 (TP53 aka p53); p53, cell cycle arrest, apoptosis and MYC; p53 and cancer; p53 is not entirely a tumour suppressor; DNA repair; Hereditary cancers; Hereditary breast cancer; Hereditary colon cancer; DNA repeats itself; Polymorphisms and cancer; Modulating gene expression without mutation: epigenetic changes; Micro RNAs (miRNAs); Conclusions; Key points; Future directions.
Responsibility: Robin Hesketh.

Abstract:

A concise overview of the fundamental concepts of cancer biology for those with little or no background in the field.  Read more...

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'Robin Hesketh has produced a remarkable introduction to cancer biology which covers all of the key areas of current knowledge and brings them up to date to current research concepts and developments Read more...

 
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