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Introduction to Cancer Metastasis

Author: Aamir Ahmad
Publisher: Academic Press, 2016.
Series: Cancer Metastasis, Volume 1
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)960278883
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Aamir Ahmad
ISBN: 9780128040331 0128040335
OCLC Number: 964920296
Notes: 1. Introduction to Cancer Metastasis>2. Breast cancer metastasis>3. Prostate cancer metastasis>4. Lung cancer metastasis>5. Colorectal cancer metastasis>6. Gastric cancer metastasis>7. Lymph node metastasis>8. Bone-metastatic cancers>9. Brain-metastatic cancers>10. Emerging therapeutic targets for cancer metastasis.
Description: 1 online resource (416 pages).
Contents: Front Cover; INTRODUCTION TO CANCER METASTASIS; Series Page; INTRODUCTION TO CANCER METASTASIS; Copyright; Contents; List of Contributors; Preface; I --
CANCER METASTASIS FROM PRIMARY ORGANS; 1 --
Cancer Metastasis: An Introduction; 1. INTRODUCTION; 2. DISRUPTION OF CELL ADHESION: INITIATION OF METASTASIS; 2.1 Adherens Junctions; 2.2 Tight Junctions; 3. MATRIX METALLOPROTEINASES IN CANCER METASTASIS; 4. EMT IN CANCER METASTASIS; 5. ORGAN-SPECIFIC METASTASIS; 6. MICRORNAS AND CANCER STEM CELLS IN CANCER METASTASIS; 7. CONCLUSIONS AND PERSPECTIVES; References; 2 --
Breast Cancer Metastasis. 1. INTRODUCTION2. BIOLOGY; 2.1 Breast Cancer Proliferation Signals; 2.2 Breast Cancer Microenvironment; 2.3 Disseminated Tumor Cells and Circulating Tumor Cells; 2.4 Breast Cancer Dormancy; 2.5 Cancer Stem Cells; 2.6 Intrinsic Subtypes; 3. METASTATIC DISSEMINATION; 3.1 Clinical Symptoms; 3.2 Locoregional Recurrence; 3.3 Bone Metastasis; 3.4 Lung Metastasis, Pleural Metastasis; 3.5 Liver Metastasis; 3.6 Brain Metastasis; 3.7 Peritoneal Dissemination; 4. PROGNOSTIC FACTORS AFTER RECURRENCE; 5. TREATMENT FOR METASTATIC BREAST CANCER; 5.1 Endocrine Therapy. 5.1.1 Selective Estrogen Receptor Modulators5.1.2 Aromatase Inhibitors; 5.1.3 Selective Estrogen Receptor Downregulators; 5.2 Chemotherapy; 5.2.1 Anthracyclines; 5.2.2 Taxanes; 5.2.3 Vinorelbine; 5.2.4 Capecitabine; 5.2.5 Eribulin; 5.2.6 Platinum Salts; 5.3 Metronomic Chemotherapy; 5.4 Molecular Targeted Therapy; 5.4.1 Trastuzumab; 5.4.2 Lapatinib; 5.4.3 T-DM1; 5.4.4 Pertuzumab; 5.4.5 Bevacizumab; 5.4.6 Everolimus; 5.5 Bisphosphonate; 5.6 RANK-Ligand (RANKL); 5.7 Radiotherapy; 5.8 Surgery; 5.9 Palliative Care; 6. CONCLUSIONS; References; 3 --
Prostate Cancer Metastasis. 1. EPIDEMIOLOGY AND OVERVIEW OF METASTATIC PROSTATE CANCER2. CELLULAR BIOLOGY OF PROSTATE CANCER METASTASES; 2.1 The Androgen Receptor Signaling Pathway; 2.2 The Phosphatidyl Inositol 3-Kinase/Akt-Signaling Pathway; 2.3 Cell Cycle Pathways; 2.4 DNA Repair Pathways; 2.5 Wnt Pathways; 2.6 Coregulator Factors; 3. THE METASTATIC CASCADE; 3.1 Bone Metastases; 3.2 Lymph Node Metastases; 3.3 Visceral Metastases; 3.4 Clinical Considerations in Prostate Cancer Metastasis; 3.4.1 Disease Recurrence and Risk Assessment; 3.5 Overview of Treatment for Prostate Cancer Metastases. 3.6 Treatment of Symptomatic Metastatic Disease3.7 Future Areas of Development; 3.8 Liquid Biopsy and Precision Medicine; 3.9 Imaging Modalities; 3.10 Investigational Therapies; 4. CONCLUSIONS; References; 4 --
Lung Cancer Metastasis; 1. GENERAL INFORMATION; 2. MECHANISM OF METASTASIS; 3. MOLECULAR MECHANISM IN THE REGULATION OF LUNG CANCER METASTASIS; 4. EPITHELIAL TO MESENCHYMAL TRANSITION IN LUNG CANCER; 5. CANCER STEM CELLS; 6. CONCLUDING REMARKS; Acknowledgments; References; 5 --
Cervical Cancer Metastasis; 1. INTRODUCTION; 2. RISK FACTORS; 3. PATHOGENESIS; 4. HISTOPATHOLOGY.
Series Title: Cancer Metastasis, Volume 1
Responsibility: Aamir Ahmad.

Abstract:

Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives.

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