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Iron acquisition by the Genus Mycobacterium : history, mechanisms, role of Siderocalin, anti-tuberculosis drug development

Author: B Rowe Byers
Publisher: Cham ; New York : Springer, ©2013.
Series: SpringerBriefs in molecular science., Biometals.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: B Rowe Byers
ISBN: 9783319003030 3319003038
OCLC Number: 845037779
Notes: Includes index.
Description: 1 online resource.
Contents: Introduction to the Book / B. Rowe Byers --
A History of Iron Metabolism in the Mycobacteria / Colin Ratledge --
Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers --
Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia --
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu.
Series Title: SpringerBriefs in molecular science., Biometals.
Responsibility: B. Rowe Byers, editor.
More information:

Abstract:

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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