RT Web Page DB /z-wcorg/ DS http://worldcat.org ID 845037779 LA English UL http://dx.doi.org/10.1007/978-3-319-00303-0 T1 Iron acquisition by the Genus Mycobacterium history, mechanisms, role of Siderocalin, anti-tuberculosis drug development A1 Byers, B. Rowe., PB Springer PP Cham; New York YR 2013 SN 9783319003030 3319003038 331900302X 9783319003023 AB Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.