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Iron acquisition by the Genus Mycobacterium : history, mechanisms, role of Siderocalin, anti-tuberculosis drug development

Autor B Rowe Byers
Vydavatel: Cham ; New York : Springer, ©2013.
Edice: SpringerBriefs in molecular science., Biometals.
Vydání/formát:   e-kniha : Document : EnglishZobrazit všechny vydání a formáty
Databáze:WorldCat
Shrnutí:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  Přečíst více...
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Detaily

Žánr/forma: Electronic books
Typ materiálu: Document, Internetový zdroj
Typ dokumentu: Internet Resource, Computer File
Všichni autoři/tvůrci: B Rowe Byers
ISBN: 9783319003030 3319003038
OCLC číslo: 845037779
Poznámky: Includes index.
Popis: 1 online resource.
Obsahy: Introduction to the Book / B. Rowe Byers --
A History of Iron Metabolism in the Mycobacteria / Colin Ratledge --
Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers --
Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia --
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu.
Název edice: SpringerBriefs in molecular science., Biometals.
Odpovědnost: B. Rowe Byers, editor.
Více informací:

Anotace:

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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