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Iron acquisition by the Genus Mycobacterium : history, mechanisms, role of Siderocalin, anti-tuberculosis drug development

Auteur : B Rowe Byers
Éditeur : Cham ; New York : Springer, ©2013.
Collection : SpringerBriefs in molecular science., Biometals.
Édition/format :   Livre électronique : Document : AnglaisVoir toutes les éditions et tous les formats
Base de données :WorldCat
Résumé :
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  Lire la suite...
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Détails

Genre/forme : Electronic books
Format – détails additionnels : Printed edition:
Type d’ouvrage : Document, Ressource Internet
Format : Ressource Internet, Fichier informatique
Tous les auteurs / collaborateurs : B Rowe Byers
ISBN : 9783319003030 3319003038 331900302X 9783319003023
Numéro OCLC : 845037779
Notes : Includes index.
Description : 1 online resource.
Contenu : Introduction to the Book / B. Rowe Byers --
A History of Iron Metabolism in the Mycobacteria / Colin Ratledge --
Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers --
Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia --
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu.
Titre de collection : SpringerBriefs in molecular science., Biometals.
Responsabilité : B. Rowe Byers, editor.
Plus d’informations :

Résumé :

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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