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Iron acquisition by the Genus Mycobacterium : history, mechanisms, role of Siderocalin, anti-tuberculosis drug development

Autor: B Rowe Byers
Editora: Cham ; New York : Springer, ©2013.
Séries: SpringerBriefs in molecular science., Biometals.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  Ler mais...
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Detalhes

Gênero/Forma: Electronic books
Tipo de Material: Documento, Recurso Internet
Tipo de Documento: Recurso Internet, Arquivo de Computador
Todos os Autores / Contribuintes: B Rowe Byers
ISBN: 9783319003030 3319003038
Número OCLC: 845037779
Notas: Includes index.
Descrição: 1 online resource.
Conteúdos: Introduction to the Book / B. Rowe Byers --
A History of Iron Metabolism in the Mycobacteria / Colin Ratledge --
Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers --
Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia --
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu.
Título da Série: SpringerBriefs in molecular science., Biometals.
Responsabilidade: B. Rowe Byers, editor.
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Resumo:

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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