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Iron acquisition by the Genus Mycobacterium : history, mechanisms, role of Siderocalin, anti-tuberculosis drug development

作者: B Rowe Byers
出版商: Cham ; New York : Springer, ©2013.
叢書: SpringerBriefs in molecular science., Biometals.
版本/格式:   電子書 : 文獻 : 英語所有版本和格式的總覽
資料庫:WorldCat
提要:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  再讀一些...
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類型/形式: Electronic books
資料類型: 文獻, 網際網路資源
文件類型: 網路資源, 電腦資料
所有的作者/貢獻者: B Rowe Byers
ISBN: 9783319003030 3319003038
OCLC系統控制編碼: 845037779
注意: Includes index.
描述: 1 online resource.
内容: Introduction to the Book / B. Rowe Byers --
A History of Iron Metabolism in the Mycobacteria / Colin Ratledge --
Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers --
Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia --
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu.
叢書名: SpringerBriefs in molecular science., Biometals.
責任: B. Rowe Byers, editor.
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摘要:

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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