skip to content
Iron Acquisition by the Genus Mycobacterium : History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development. Preview this item
ClosePreview this item
Checking...

Iron Acquisition by the Genus Mycobacterium : History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development.

Author: B Rowe Byers
Publisher: Dordrecht : Springer, 2013.
Series: Springerbriefs in Molecular Science / Springerbriefs in Biometals.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Byers, B. Rowe.
Iron Acquisition by the Genus Mycobacterium : History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: B Rowe Byers
ISBN: 9783319003030 3319003038
OCLC Number: 854975594
Description: 1 online resource (96 pages).
Contents: Iron Acquisition by the Genus Mycobacterium; Contents; 1 Introduction to the Book; 1.1 The Value, Danger, and Capture of Iron by Bacteria; 1.2 Scope of the Book; 2 A History of Iron Metabolism in the Mycobacteria; Abstract; 2.1 Introduction; 2.2 The Trouble with Iron; 2.3 Iron as an Essential Nutrient for Mycobacteria; 2.4 Early Discoveries of the Major Components of Iron Acquisition by Mycobacteria; 2.4.1 The Mycobactins; 2.4.2 Other Mycobactins and Related Lipid-Soluble Siderophores; 2.4.3 Salicylic Acid; 2.5 Extracellular Siderophores of Mycobacteria; 2.5.1 The Problem with Mycobactin. 2.5.2 The Water-Soluble Exochelins2.5.3 The Carboxymycobactins; 2.6 Putting it All Together; References; 3 Mycobacterial Iron Acquisition Mechanisms; Abstract; 3.1 The Need for Siderophores in Iron Acquisition; 3.2 The "Iron Biofulcrum" of Infectious Diseases; 3.3 The Mycobacterial Siderophores and Iron Acquisition: Mycobactin, Carboxymycobactin, and Exochelin; 3.4 Mycobacterial Iron Acquisition from Heme; 3.5 Ferritin and Mycobacterial Persistence in Animals; 3.6 Low Affinity and Reductive Mycobacterial Iron Acquisition. 3.7 Iron and Continuous Growth of M. smegmatis in a Teflon Chemostat: Biofilm Formation3.8 The Complexity and Perplexity of Mycobacterial Iron Acquisition: Conclusions; References; 4 Siderocalin Combats Mycobacterial Infections; Abstract; 4.1 Siderocalin; 4.2 Role of Siderophores in Mycobacterial Infections; 4.3 Scn Binds Carboxymycobactins; 4.4 Scn Location and Contact with Mycobacteria; 4.5 Concluding Remarks; References; 5 Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis; Abstract; 5.1 Introduction. 5.2 Bacterial Iron Acquisition5.3 Siderophore System in M. tuberculosis; 5.4 Siderophore-Antibiotic Conjugates; 5.5 Mycobactin Analogs are Growth Inhibitors of M. tuberculosis; 5.6 Small Molecule Anti-TB Agents Derived from Studies of the Oxazoline Component of Mycobactins; 5.7 A Mycobactin Siderophore-Antibiotic Conjugate Selectively Targets M. tuberculosis; 5.8 Inhibition of MbtA Nonribosomal Peptide Synthetase; 5.9 Inhibition of MbtI Nonribosomal Peptide Synthetase; 5.10 Conclusions; References; Index.
Series Title: Springerbriefs in Molecular Science / Springerbriefs in Biometals.

Abstract:

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the des.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


<http://www.worldcat.org/oclc/854975594>
library:oclcnum"854975594"
library:placeOfPublication
library:placeOfPublication
rdf:typeschema:MediaObject
rdf:typeschema:Book
rdf:valueUnknown value: dct
schema:about
schema:bookFormatschema:EBook
schema:creator
schema:datePublished"2013"
schema:description"Iron Acquisition by the Genus Mycobacterium; Contents; 1 Introduction to the Book; 1.1 The Value, Danger, and Capture of Iron by Bacteria; 1.2 Scope of the Book; 2 A History of Iron Metabolism in the Mycobacteria; Abstract; 2.1 Introduction; 2.2 The Trouble with Iron; 2.3 Iron as an Essential Nutrient for Mycobacteria; 2.4 Early Discoveries of the Major Components of Iron Acquisition by Mycobacteria; 2.4.1 The Mycobactins; 2.4.2 Other Mycobactins and Related Lipid-Soluble Siderophores; 2.4.3 Salicylic Acid; 2.5 Extracellular Siderophores of Mycobacteria; 2.5.1 The Problem with Mycobactin."@en
schema:description"Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the des."@en
schema:exampleOfWork<http://worldcat.org/entity/work/id/1379432227>
schema:genre"Electronic books"@en
schema:inLanguage"en"
schema:isPartOf
schema:name"Iron Acquisition by the Genus Mycobacterium History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development."@en
schema:publication
schema:publisher
schema:url<http://public.eblib.com/choice/publicfullrecord.aspx?p=1317006>
schema:workExample
wdrs:describedby

Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.