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|Additional Physical Format:||Print version:
Byers, B. Rowe.
Iron Acquisition by the Genus Mycobacterium : History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development.
Dordrecht : Springer, ©2013
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
B Rowe Byers
|Description:||1 online resource (96 pages).|
|Contents:||Iron Acquisition by the Genus Mycobacterium; Contents; 1 Introduction to the Book; 1.1 The Value, Danger, and Capture of Iron by Bacteria; 1.2 Scope of the Book; 2 A History of Iron Metabolism in the Mycobacteria; Abstract; 2.1 Introduction; 2.2 The Trouble with Iron; 2.3 Iron as an Essential Nutrient for Mycobacteria; 2.4 Early Discoveries of the Major Components of Iron Acquisition by Mycobacteria; 2.4.1 The Mycobactins; 2.4.2 Other Mycobactins and Related Lipid-Soluble Siderophores; 2.4.3 Salicylic Acid; 2.5 Extracellular Siderophores of Mycobacteria; 2.5.1 The Problem with Mycobactin. 2.5.2 The Water-Soluble Exochelins2.5.3 The Carboxymycobactins; 2.6 Putting it All Together; References; 3 Mycobacterial Iron Acquisition Mechanisms; Abstract; 3.1 The Need for Siderophores in Iron Acquisition; 3.2 The "Iron Biofulcrum" of Infectious Diseases; 3.3 The Mycobacterial Siderophores and Iron Acquisition: Mycobactin, Carboxymycobactin, and Exochelin; 3.4 Mycobacterial Iron Acquisition from Heme; 3.5 Ferritin and Mycobacterial Persistence in Animals; 3.6 Low Affinity and Reductive Mycobacterial Iron Acquisition. 3.7 Iron and Continuous Growth of M. smegmatis in a Teflon Chemostat: Biofilm Formation3.8 The Complexity and Perplexity of Mycobacterial Iron Acquisition: Conclusions; References; 4 Siderocalin Combats Mycobacterial Infections; Abstract; 4.1 Siderocalin; 4.2 Role of Siderophores in Mycobacterial Infections; 4.3 Scn Binds Carboxymycobactins; 4.4 Scn Location and Contact with Mycobacteria; 4.5 Concluding Remarks; References; 5 Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis; Abstract; 5.1 Introduction. 5.2 Bacterial Iron Acquisition5.3 Siderophore System in M. tuberculosis; 5.4 Siderophore-Antibiotic Conjugates; 5.5 Mycobactin Analogs are Growth Inhibitors of M. tuberculosis; 5.6 Small Molecule Anti-TB Agents Derived from Studies of the Oxazoline Component of Mycobactins; 5.7 A Mycobactin Siderophore-Antibiotic Conjugate Selectively Targets M. tuberculosis; 5.8 Inhibition of MbtA Nonribosomal Peptide Synthetase; 5.9 Inhibition of MbtI Nonribosomal Peptide Synthetase; 5.10 Conclusions; References; Index.|
|Series Title:||Springerbriefs in Molecular Science / Springerbriefs in Biometals.|